--- title: What are the main trends in research about premenstrual disorders and related conditions? description: Research on premenstrual disorders has grown steadily from 1999 to 2023. Most research comes from North America. Scientists are increasingly studying connecti url: https://niyora.com/research/papers/a-global-perspective-trends-and-insights-in-premenstrual-disorder-comorbidity-2025/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - What are the main trends in research about premenstrual disorders and related conditions? Systematic review, 2025 # What are the main trends in research about premenstrual disorders and related conditions? Research on premenstrual disorders has grown steadily from 1999 to 2023. Most research comes from North America. Scientists are increasingly studying connections between PMDD and bipolar disorder. Moderate study design Published research papers on premenstrual disorders from 1999 to 2023 (149 papers analyzed) ## What they did The researchers analyzed 149 published scientific papers about premenstrual disorders and conditions that occur together with them from 1999 to 2023. They used software tools to examine publication patterns by country, institution, journal, author, and research topic. ## What they found The number of publications grew from 1999 to 2023. The US and Canada published the most research. McMaster University and Harvard University produced the most influential work. Frey BN from McMaster University was the most prolific author. The American Journal of Psychiatry was the most-cited journal (impact factor 17.7). Research shifted over time from counting how many people have these conditions to studying how the conditions develop and how to diagnose them. The connection between PMDD and bipolar disorder emerged as a rising research focus. ## What it means for you This study tracks what scientists are researching, not whether treatments work. Scientists are paying more attention to premenstrual disorders, especially in North America. The growing focus on the connection between PMDD and bipolar disorder suggests this is an important area to study further. 149 Published papers analyzed 1999-2023 Time period covered 17.7 Impact factor of most-cited journal ## About the study Original title A global perspective: Trends and insights in premenstrual disorder comorbidity research by bibliometric analysis (1999-2023) Authors Cheng X, Li H, Gao M et al. Journal Medicine Year 2025 Study design Systematic review What was tested Not applicable - this is a study of research trends Open access Yes Read the paper [doi.org/10.1097/md.0000000000045001](https://doi.org/10.1097/md.0000000000045001) Original abstract Background: Premenstrual disorders represent a constellation of incapacitating gynecological disorders with numerous coexisting conditions. The identification and comprehension of disease-related comorbidities are of paramount importance in the medical field. This study aims to systematically review existing research and identify potential focus areas through bibliometric analysis. Methods: One hundred forty-nine publications on comorbidity in psychotic mood disorders between 1999 and 2023 were retrieved from the Web of Science Core Collection. The data was analyzed using bibliometric tools such as CiteSpace 6.1.R2 and VOSviewer. Specifically, the study examined the annual publication count, contributions by country and institution and details on journals, authors, citation counts, and keywords. Results: The data were retrieved on August 3, 2023. The annual number of publications showed an upward trend from 1999 to 2023. Globally, the US and Canada presented the highest publication counts and served as core research regions. Meanwhile, McMaster University and Harward University exhibited the highest output and influence by institution. In terms of author, Frey BN (McMaster University, Canada) was the most prolific with leading academic influence, while Lieb R (University of Basel, Switzerland) and Wittchen HU (Technical University Dresden, Germany) were the most cited authors. The American Journal of Psychiatry (impact factor = 17.7, 2023) was the most frequently cited journal. Furthermore, significant overlapping between premenstrual syndrome and premenstrual dysphoric disorder warrants further investigation, and the intrinsic connection between premenstrual dysphoric disorder and bipolar disorder is a rising focus. Temporally, research shifted from prevalence surveys to diagnostic and mechanistic studies. Conclusions: This bibliometric study comprehensively analyzes the current state of research on physical and mental health comorbidities. North America became a prominent leader in contributions from countries, institutions, authors, and journals. Additionally, the study underscores the potential for further exploration of comorbidity between physiological and psychiatric conditions, suggesting a promising avenue for future research efforts. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2018 How common is PMDD in women with psychiatric disorders? Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Survey study, 2026 What is the true rate of PMDD, and does it worsen mental health conditions? Review, 2025 How does the menstrual cycle affect psychiatric symptoms like depression and anxiety? Survey study, 2022 What factors make PMS mood swings worse? Case report, 2013 Can high testosterone levels be connected to PMDD, bipolar disorder, and certain medications? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗