---
title: Does a topical gel help acne around your period? | Niyora
description: Yes, the combination gel improved period-related acne in all 22 women with no serious side effects. The study was very small with no comparison group.
url: https://niyora.com/research/papers/a-pilot-study-of-clindamycin-phosphate-1-2-and-benzoyl-peroxide-3-75-combination-2022/
---

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- Does a topical gel help acne around your period?

Non-randomised trial, 2022

# Does a topical gel help acne around your period?

Yes, the combination gel improved period-related acne in all 22 women with no serious side effects. The study was very small with no comparison group.

 Early or limited evidence

22 adult women with acne around their period

## What they did

A pilot study where 22 adult women with period acne applied a combination gel daily for 99 days. Doctors measured improvement every 14 days using a standard acne scoring system.

## What they found

There was significant improvement in acne scores and the number of acne lesions. All 22 women tolerated the medication well with no serious adverse effects.

## What it means for you

This topical gel might be a good option for period acne instead of hormonal birth control. Main limitation: very small sample and no comparison group, so larger studies are needed to confirm it works.

22

women

99 days

treatment duration

daily

application frequency

## About the study

Original title A Pilot Study of Clindamycin Phosphate 1.2% and Benzoyl Peroxide 3.75% Combination Gel in the Treatment of Perimenstrual Acne Authors Marushchak O, Gagliotti M, Vekaria AS et al. Journal The Journal of clinical and aesthetic dermatology Year 2022 Study design Non-randomised trial Participants 22 What was tested Clindamycin phosphate 1.2% and benzoyl peroxide 3.75% combination gel Open access Yes Read the paper [https://pubmed.ncbi.nlm.nih.gov/36381180/](https://pubmed.ncbi.nlm.nih.gov/36381180/)

## Topics

[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)

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