--- title: Does the COVID-19 booster vaccine affect menstrual cycles in adolescent girls? description: Yes. Girls who received the booster had shorter cycles on average, with cycles being 5.35 days shorter than before vaccination, especially in the second cycle url: https://niyora.com/research/papers/a-prospective-study-of-the-relationship-of-covid-19-vaccination-to-menstrual-2024/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does the COVID-19 booster vaccine affect menstrual cycles in adolescent girls? Cohort study, 2024 # Does the COVID-19 booster vaccine affect menstrual cycles in adolescent girls? Yes. Girls who received the booster had shorter cycles on average, with cycles being 5.35 days shorter than before vaccination, especially in the second cycle after vaccination. Higher stress was also linked to shorter cycles. Moderate study design 65 adolescent girls aged 13-20 in the United States (47 received COVID-19 booster, 18 did not) ## What they did A prospective study comparing 47 adolescent girls who received a COVID-19 booster vaccine to 18 who did not, all aged 13-20 in the United States. The vaccinated group was tracked for 3 cycles before and 4 cycles after vaccination. The unvaccinated group was tracked for 7 cycles. Researchers measured cycle length, flow, pain, and menstrual symptoms monthly and assessed stress at baseline. ## What they found Girls in the booster group experienced cycles that were on average 5.35 days shorter after vaccination, particularly in the second cycle. The unvaccinated group showed no changes in cycle length. Higher stress was linked to shorter cycles and more menstrual symptoms, regardless of group. There were no differences in menstrual flow, pain, or symptoms between groups. ## What it means for you The booster vaccine was linked to shorter cycles in adolescent girls. The effect appeared temporary or localized to the second cycle. Higher stress also affected cycle length. This is a small study and researchers note further investigation is needed to understand the mechanism. The sample may not represent all adolescents. 47 Adolescents in booster group 18 Adolescents in unvaccinated control group 5.35 Average days shorter in postbooster cycles ## About the study Original title A Prospective Study of the Relationship of COVID-19 Vaccination to Menstrual Cycle Characteristics in Adolescent Girls Authors Payne LA, Seidman LC, Granger SW et al. Journal The Journal of adolescent health : official publication of the Society for Adolescent Medicine Year 2024 Study design Cohort study Participants 65 What was tested COVID-19 booster vaccine Open access Yes Read the paper [doi.org/10.1016/j.jadohealth.2024.06.023](https://doi.org/10.1016/j.jadohealth.2024.06.023) ## Topics [Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Stress](https://niyora.com/research/topics/symptom-stress/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2025 How common is PMS in Chinese teenage girls, and what factors are linked to it? Cohort study, 2024 Is there a link between sleep and menstrual problems in teenage girls? Survey study, 2025 Do menstrual problems and poor sleep affect mood and thinking in teenage girls? Survey study, 2025 Does menstruation affect how well women perform at work? Survey study, 2024 Does poor sleep and period problems affect teen mental health? Survey study, 2024 What attitudes do women have about menstruation and what affects these attitudes? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗