---
title: Does danazol help severe PMS? | Niyora
description: Yes, danazol significantly reduced severe PMS symptoms compared to placebo, with 43.8 percent of women becoming symptom-free versus 8.3 percent on placebo.
url: https://niyora.com/research/papers/a-randomized-placebo-controlled-crossover-trial-of-danazol-for-the-treatment-of-1995/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Does danazol help severe PMS?

Randomised trial, 1995

# Does danazol help severe PMS?

Yes, danazol significantly reduced severe PMS symptoms compared to placebo, with 43.8 percent of women becoming symptom-free versus 8.3 percent on placebo.

 Moderate study design

Twenty-eight women with severe PMS

## What they did

Twenty-eight women with severe PMS completed a randomized, double-blind crossover study. They received either danazol 200 mg twice daily or placebo for three consecutive cycles, then switched to the other treatment.

## What they found

Symptom scores dropped by an average of 14.0 points on danazol compared to 3.6 points on placebo. Seven of 16 women on danazol (43.8%) reached symptom-free status compared to one of 12 women on placebo (8.3%).

## What it means for you

Danazol is significantly more effective than placebo for severe PMS, with nearly half of women becoming symptom-free. The study was small and the crossover design had some technical complications affecting the analysis.

28

women completed

200 mg

danazol dose twice daily

43.8%

became symptom-free on danazol

## About the study

Original title A randomized, placebo-controlled, crossover trial of danazol for the treatment of premenstrual syndrome Authors Hahn PM, Van Vugt DA, Reid RL Journal Psychoneuroendocrinology Year 1995 Study design Randomised trial Participants 28 What was tested Danazol 200 mg twice daily for three cycles versus placebo Read the paper [doi.org/10.1016/0306-4530(94)00053-d](https://doi.org/10.1016/0306-4530(94)00053-d)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Cohort study, 2025

How common is PMS in Chinese teenage girls, and what factors are linked to it?

Review, 2018

Which women are most likely to experience hot flashes during menopause?

Review, 2003

How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD?

Randomised trial, 2003

Are SSRI antidepressants effective for PMDD?

Randomised trial, 1999

Do SSRIs reduce premenstrual dysphoria symptoms?

Randomised trial, 1995

Does fluoxetine help premenstrual dysphoria?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗