--- title: Do women with a history of PMS react differently to hormone therapy after menopause? description: Yes. Women with a history of PMS had worse mood symptoms when progestin was added to estrogen, especially those with anxiety-related personality traits. url: https://niyora.com/research/papers/adverse-mood-effects-during-postmenopausal-hormone-treatment-in-relation-to-2006/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do women with a history of PMS react differently to hormone therapy after menopause? Randomised trial, 2006 # Do women with a history of PMS react differently to hormone therapy after menopause? Yes. Women with a history of PMS had worse mood symptoms when progestin was added to estrogen, especially those with anxiety-related personality traits. Moderate study design 106 postmenopausal women stratified by history of PMS ## What they did An analysis of 106 postmenopausal women who had completed sequential hormone therapy clinical trials. Women received 2 mg estradiol continuously, with 10 mg medroxyprogesterone acetate added for the last 12 days of a 28-day cycle. Researchers compared mood symptoms and personality traits in women with versus without a history of PMS. ## What they found Women with a PMS history reported worse mood when progestin was added. Those with the worst mood during the progestin phase had higher baseline anxiety, lower life satisfaction, more indirect aggression and irritability. Women with prior PMS had higher baseline anxiety, muscular tension, indirect aggression, and lower life satisfaction than women without PMS history. ## What it means for you Women with prior PMS may need careful evaluation before starting hormone therapy after menopause, especially those with anxiety-related personality traits. This was an observational study of past trial data, not a randomized trial, so it cannot prove cause and effect. 106 postmenopausal women studied 2 mg daily estradiol valerate 10 mg medroxyprogesterone acetate (12 days) ## About the study Original title Adverse mood effects during postmenopausal hormone treatment in relation to personality traits Authors Björn I, Bäckström T, Lalos A et al. Journal Climacteric : the journal of the International Menopause Society Year 2006 Study design Randomised trial Participants 106 What was tested Sequential estrogen and progestin (2 mg estradiol continuously, plus 10 mg medroxyprogesterone acetate for 12 days per cycle) Read the paper [doi.org/10.1080/13697130600865766](https://doi.org/10.1080/13697130600865766) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 1999 Is premenstrual dysphoric disorder a distinct clinical disorder? Survey study, 2019 Can birth control pills treat PMDD? Survey study, 2011 Why do some women experience negative mood with hormone changes? Survey study, 2009 Why do some women feel depressed or anxious when progesterone increases before their period? Systematic review, 2008 What treatments work best for PMS and PMDD? Review, 2003 How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗