---
title: Does alprazolam help women with late luteal phase dysphoric disorder?
description: Yes, but only for women whose symptoms happen only in the luteal phase. It reduced tension, irritability, and anxiety in that group but not in women who also
url: https://niyora.com/research/papers/alprazolam-in-the-treatment-of-two-subsamples-of-patients-with-late-luteal-phase-1994/
---

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- Does alprazolam help women with late luteal phase dysphoric disorder?

Randomised trial, 1994

# Does alprazolam help women with late luteal phase dysphoric disorder?

Yes, but only for women whose symptoms happen only in the luteal phase. It reduced tension, irritability, and anxiety in that group but not in women who also had anxiety or depression at other times of the month.

 Moderate study design

Women with late luteal phase dysphoric disorder, in two groups with different symptom patterns

## What they did

Women took alprazolam and placebo for 3 months each in a crossover design. The study separated women into two groups: those with only LLPDD, and those with LLPDD plus anxiety or depression in other phases of the cycle.

## What they found

In the first group, alprazolam significantly reduced tension, irritability, anxiety, and feelings of being out of control compared to placebo. Few side effects were reported. In the second group, alprazolam and placebo showed no difference.

## What it means for you

Alprazolam helps only women with pure LLPDD, not those with ongoing mood symptoms. Side effects were dose-related.

0.25 mg

dose, three times daily

3 months

duration of each treatment phase

4

symptom types reduced

## About the study

Original title Alprazolam in the treatment of two subsamples of patients with late luteal phase dysphoric disorder: a double-blind, placebo-controlled crossover study Authors Berger CP, Presser B Journal Obstetrics and gynecology Year 1994 Study design Randomised trial What was tested Alprazolam 0.25 mg three times daily Read the paper [https://pubmed.ncbi.nlm.nih.gov/8058235/](https://pubmed.ncbi.nlm.nih.gov/8058235/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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How common is premenstrual dysphoric disorder and how is it related to other psychiatric conditions?

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Cohort study, 2020

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Randomised trial, 2017

Does Sepranolone reduce symptoms of severe premenstrual syndrome (PMDD)?

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