---
title: Does a supplement with krill oil, vitamins, and plant ingredients help PMS symptoms?
description: Yes. All 29 women reported significant improvement in 10 PMS symptoms after 3 months. However, this open-label study had no control group, so improvement migh
url: https://niyora.com/research/papers/an-open-label-pilot-study-to-assess-the-effectiveness-of-krill-oil-with-added-2013/
---

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- Does a supplement with krill oil, vitamins, and plant ingredients help PMS symptoms?

Randomised trial, 2013

# Does a supplement with krill oil, vitamins, and plant ingredients help PMS symptoms?

Yes. All 29 women reported significant improvement in 10 PMS symptoms after 3 months. However, this open-label study had no control group, so improvement might partly be due to placebo effect.

 Early or limited evidence

Women with PMS

## What they did

29 women with PMS took a daily supplement containing thiamine, riboflavin, pyridoxine, vitamin D, soy isoflavones, rosemary extract, and krill oil for 3 months. This was an open-label pilot study, meaning women knew they were taking the supplement and there was no control group.

## What they found

All 29 women reported statistically significant improvement in anxiety, bloating, mood swings, breast tenderness, skin outbreaks, food cravings, fatigue, forgetfulness, insomnia, and headache.

## What it means for you

This supplement combination may help multiple PMS symptoms, but since this is an open-label study with no placebo control, the improvement might be partly due to placebo effect. A larger placebo-controlled study is planned.

29

women in study

3 months

duration of treatment

## About the study

Original title An open-label pilot study to assess the effectiveness of krill oil with added vitamins and phytonutrients in the relief of symptoms of PMS Authors Michael Wakeman Journal Nutrition and Dietary Supplements Year 2013 Study design Randomised trial Participants 29 What was tested Supplement with krill oil, vitamins B1, B2, B6, D, soy isoflavones, and rosemary extract Open access Yes Read the paper [doi.org/10.2147/nds.s48133](https://doi.org/10.2147/nds.s48133)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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