---
title: Is a gene variant linked to PMDD? | Niyora
description: No, this particular gene variant was not associated with PMDD. This does not rule out other genetic factors or that PMDD has a genetic basis.
url: https://niyora.com/research/papers/analysis-of-the-serotonin-transporter-promoter-rs25531-polymorphism-in-2010/
---

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- Is a gene variant linked to PMDD?

Case-control study, 2010

# Is a gene variant linked to PMDD?

No, this particular gene variant was not associated with PMDD. This does not rule out other genetic factors or that PMDD has a genetic basis.

 Moderate study design

53 women with diagnosed PMDD (age 27-46, mean 37.7) vs 52 healthy controls (age 22-48, mean 36.2)

## What they did

The study compared a specific gene variant (rs25531) in women with diagnosed PMDD and healthy controls. They tested 53 women with PMDD and 52 controls and also tested a related gene variant.

## What they found

There was no significant difference in the gene variant between the PMDD and control groups. Neither this variant alone nor combined with a related variant was associated with PMDD.

## What it means for you

This particular gene variant does not appear to be a major factor in PMDD. However, this does not rule out other genetic factors. The study size was moderate, so larger studies might find different results.

53

Women with PMDD

52

Control women

37.7

Mean age of PMDD group

## About the study

Original title Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder Authors Magnay JL, El-Shourbagy M, Fryer AA et al. Journal American journal of obstetrics and gynecology Year 2010 Study design Case-control study Participants 53 What was tested Gene variant testing (genotyping) Read the paper [doi.org/10.1016/j.ajog.2010.02.043](https://doi.org/10.1016/j.ajog.2010.02.043)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Athletes and sport](https://niyora.com/research/topics/life-area-athletes/)

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