--- title: Is PMDD common in women with lupus and linked to depression? | Niyora description: Yes. 32% of women with lupus had PMDD, and this was significantly associated with major depression (p=0.010). url: https://niyora.com/research/papers/association-between-premenstrual-dysphoric-disorder-and-systemic-lupus-2013/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Is PMDD common in women with lupus and linked to depression? Survey study, 2013 # Is PMDD common in women with lupus and linked to depression? Yes. 32% of women with lupus had PMDD, and this was significantly associated with major depression (p=0.010). Early or limited evidence 62 women with systemic lupus erythematosus ## What they did Cross-sectional study of 62 women with systemic lupus erythematosus (SLE). Participants completed a sociodemographic questionnaire and Mini International Neuropsychiatric Interview to assess for PMDD, depression, dysthymia, and anxiety. ## What they found 20 of 62 patients (32%) had premenstrual dysphoric disorder. PMDD was significantly associated with major depression (p=0.010) but not with dysthymia (p=0.063) or anxiety (p=0.223). ## What it means for you Women with lupus have high rates of PMDD, and PMDD appears linked to major depression in this group. However, this was a small study at one clinic, so we cannot say whether PMDD causes depression or vice versa. 32% had PMDD p=0.010 significance for depression 62 women studied ## About the study Original title Association between Premenstrual Dysphoric Disorder and Systemic Lupus Erythematosus: Exacerbation of Major Depression Symptoms? Authors Sílvia Fernanda Cal, Lorena Cal Alonso, Amanda Galvão-de Almeida et al. Journal Open Journal of Rheumatology and Autoimmune Diseases Year 2013 Study design Survey study What was tested None Open access Yes Read the paper [doi.org/10.4236/ojra.2013.34032](https://doi.org/10.4236/ojra.2013.34032) Original abstract Introduction: Systemic Lupus Erythematosus (SLE) usually presents neuropsychiatric manifestations, such as psychosis, convulsion, mood disorder and chronic headache, with mood disorder being the most prevalent. It is also known that other psychiatric disorders and menstrual cycle disorders are frequent in SLE. The aim of this study was to describe for the first time the frequency of premenstrual dysphoric disorder in patients with SLE diagnosis, and its association with depression and anxiety. Material and Methods: An evaluation was made of 62 (sixty-two) patients with diagnosis of SLE, based on the American College of Rheumatology criteria, who received follow-up care at an ambulatory reference center. The patients were submitted to a sociodemographic evaluation questionnaire, upon which the Mini International Neuropsychiatric Interview (MINI PLUS), Brazilian Version 5.0.0, was used to evaluate the diagnosis. Results: Twenty (32%) patients were found to have premenstrual dysphoric disorder, and there was a statistically significant association with major depression (p = 0.010), but no statistical significance was found with dysthymia (p = 0.063) or anxiety (p = 0.223). Conclusions: The frequency of premenstrual dysphoric disorder (PMDD) in patients with SLE was high, as well as the frequency of major depression in this group. There was an association between these two disorders. Reproduced under CC-BY. ## Topics [Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Case report, 2013 Can severe mood changes around a period be an early sign of bipolar disorder? Review, 2006 When mood changes seem tied to your cycle, is it actually PMDD? Survey study, 2001 How common is premenstrual dysphoric disorder and how is it related to other psychiatric conditions? Non-randomised trial, 2008 Can the Sheehan Disability Scale measure whether treatments work? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗