--- title: Does having PMS or PMDD before pregnancy increase the risk of depression during and after pregnancy? description: Yes. Women with PMS or PMDD before pregnancy had a higher risk of depression during pregnancy and in the first month after birth. url: https://niyora.com/research/papers/association-of-premenstrual-disorders-during-preconception-with-perinatal-2024/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does having PMS or PMDD before pregnancy increase the risk of depression during and after pregnancy? Survey study, 2024 # Does having PMS or PMDD before pregnancy increase the risk of depression during and after pregnancy? Yes. Women with PMS or PMDD before pregnancy had a higher risk of depression during pregnancy and in the first month after birth. Moderate study design 789 pregnant women at a Japanese hospital, 54 of whom had PMS or PMDD before pregnancy ## What they did 789 pregnant women at one Japanese hospital were asked about PMS or PMDD symptoms they had before they got pregnant. Doctors measured depression using a screening tool during pregnancy and one month after birth. ## What they found 54 women had PMS or PMDD before pregnancy. Women with preconception PMS or PMDD were more likely to have high depression scores during pregnancy and one month after birth than women without it. ## What it means for you Women with PMS or PMDD before getting pregnant are at higher risk of depression during pregnancy and after birth. Doctors should ask about PMS or PMDD at early pregnancy appointments and provide early mental health support to women at risk. The main limit is this was one hospital in Japan, so results may differ elsewhere. 789 pregnant women studied 54 women with preconception PMS or PMDD ## About the study Original title Association of premenstrual disorders during preconception with perinatal depression: an analysis of the perinatal clinical database of a single Japanese institution Authors Ohsuga T, Egawa M, Tsuyuki K et al. Journal Research Square Year 2024 Study design Survey study Participants 789 What was tested None. This was an observational study. Read the paper [doi.org/10.21203/rs.3.rs-5126114/v1](https://doi.org/10.21203/rs.3.rs-5126114/v1) Original abstract Abstract Background Recent studies have identified premenstrual disorders (PMDs) as a risk factor for postpartum depression. However, routine screening for preconception PMDs is not yet common in Japan. This study investigated the association between preconception PMDs and perinatal depression in a single tertiary care setting. Methods We analyzed data from pregnant women who delivered at Kyoto University Hospital between April 2020 and October 2023. PMDs during preconception was assessed using the Premenstrual Symptoms Screening Tool, whereas perinatal depression was measured using the Edinburgh Postnatal Depression Scale (EPDS) during pregnancy and at 1 month postpartum. EPDS cutoff values were set at 12/13 during pregnancy and 8/9 at 1 month postpartum. Results Of 789 women analyzed, 54 had preconception PMDs. Univariate and multivariate logistic regression analyses revealed that preconception PMDs was associated with an EPDS score of ≥ 13 during pregnancy, with a crude odds ratio (OR) of 5.64 (95% confidence interval [CI]: 2.64–11.5) and an adjusted OR of 3.63 (95% CI: 1.51–8.14). For an EPDS score of ≥ 9 at 1 month postpartum, the crude OR was 3.22 (95% CI: 1.72–5.85) and the adjusted OR was 2.10 (95% CI: 1.01–4.20). Conclusions Our findings indicate that preconception PMDs is a significant risk factor for both depression during pregnancy and postpartum depression. These results support the implementation of preconception PMDs screening during antenatal checkups to identify women in need of early mental health care and preventive measures. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2026 Does having PMS before pregnancy increase the risk of postpartum depression? Systematic review, 2026 Why do some women experience mood changes linked to their menstrual cycle? Cohort study, 2026 Do premenstrual disorder and postpartum depression share the same genetic causes? Cohort study, 2025 Is there a link between premenstrual disorders and autoimmune disease? Cohort study, 2025 Do women with a history of PMS or PMDD have more depression during pregnancy and after birth? Case-control study, 2024 Do steroid hormone levels change differently across the menstrual cycle in women with PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗