---
title: Are seasonal mood changes and premenstrual symptoms both common in women with bipolar disorder?
description: Yes, particularly in bipolar II disorder. Women with bipolar disorder experience both seasonal and premenstrual mood changes, and these two cycles appear to b
url: https://niyora.com/research/papers/association-of-seasonality-and-premenstrual-symptoms-in-bipolar-i-and-bipolar-ii-2011/
---

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- Are seasonal mood changes and premenstrual symptoms both common in women with bipolar disorder?

Case-control study, 2011

# Are seasonal mood changes and premenstrual symptoms both common in women with bipolar disorder?

Yes, particularly in bipolar II disorder. Women with bipolar disorder experience both seasonal and premenstrual mood changes, and these two cycles appear to be related.

 Moderate study design

61 women with bipolar I or II disorder and 122 healthy women.

## What they did

Case-control study comparing 61 women with bipolar I or II disorder to 122 healthy women, measuring lifetime seasonality and premenstrual symptoms using questionnaires.

## What they found

Patients with bipolar disorder had higher seasonality scores than healthy controls, with a more prominent difference in bipolar II (p<0.0001) than bipolar I (p=0.001). Among women with bipolar II, 51.6% had moderate to severe PMS compared to 19.7% of controls. Seasonality and PMS were significantly associated in both groups.

## What it means for you

Women with bipolar II disorder especially experience regular cyclical changes related to both seasons and menstrual cycles, possibly through a shared biological mechanism. Study size and single-country scope limit generalizability.

61

women with bipolar disorder

51.6%

bipolar II women with moderate-severe PMS

19.7%

controls with moderate-severe PMS

## About the study

Original title Association of seasonality and premenstrual symptoms in bipolar I and bipolar II disorders Authors Choi J, Baek JH, Noh J et al. Journal Journal of affective disorders Year 2011 Study design Case-control study Participants 122 What was tested Assessment only (no treatment). Read the paper [doi.org/10.1016/j.jad.2010.07.030](https://doi.org/10.1016/j.jad.2010.07.030)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)

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## Related studies

Systematic review, 2026

How often do mood disorders and PMS or PMDD occur together?

Cohort study, 2023

Are PMS symptoms linked to genetic factors for psychiatric disorders?

Cohort study, 2023

Is PMDD a valid medical diagnosis?

Systematic review, 2022

Do mental health disorders get worse during the menstrual cycle?

Systematic review, 2012

Do women with both bipolar disorder and PMS or PMDD need different treatment?

Study, 2026

How often do people have both PMDD and bipolar disorder together, and how do they affect each other?

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