---
title: Do anti-CGRP antibodies work the same for period-related migraines as other migraines?
description: Yes. Both period-related and non-period-related migraine days improved equally when treated with anti-CGRP antibodies.
url: https://niyora.com/research/papers/both-perimenstrual-and-nonperimenstrual-migraine-days-respond-to-anti-calcitonin-2023/
---

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- Do anti-CGRP antibodies work the same for period-related migraines as other migraines?

Non-randomised trial, 2023

# Do anti-CGRP antibodies work the same for period-related migraines as other migraines?

Yes. Both period-related and non-period-related migraine days improved equally when treated with anti-CGRP antibodies.

 Early or limited evidence

Women with migraine

## What they did

Women with migraine tracked migraine days using electronic diaries during one baseline month and 6 months of treatment with either erenumab or fremanezumab.

## What they found

Treatment reduced migraine days similarly whether they occurred around the menstrual window or at other times (odds ratio 0.44, 95% CI 0.38-0.51).

## What it means for you

Anti-CGRP antibodies reduce menstrual-related migraines as effectively as other migraines. Main limit: single-arm study with no comparison group.

0.44

Odds ratio for migraine days under treatment

6

Months of treatment

0.38-0.51

95% confidence interval

## About the study

Original title Both perimenstrual and nonperimenstrual migraine days respond to anti-calcitonin gene-related peptide (receptor) antibodies Authors Verhagen IE, de Vries Lentsch S, van der Arend BWH et al. Journal European journal of neurology Year 2023 Study design Non-randomised trial What was tested erenumab or fremanezumab (anti-CGRP antibodies) Open access Yes Read the paper [doi.org/10.1111/ene.15794](https://doi.org/10.1111/ene.15794)

## Topics

[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/)

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