---
title: Can hormones trigger PMS symptoms in women without ovaries or a uterus?
description: Not clearly. Some individual women showed links between progesterone and symptoms, but results overall were not statistically significant. Women don't respond
url: https://niyora.com/research/papers/can-one-induce-premenstrual-symptomatology-in-women-with-prior-hysterectomy-and-1996/
---

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- Can hormones trigger PMS symptoms in women without ovaries or a uterus?

Cohort study, 1996

# Can hormones trigger PMS symptoms in women without ovaries or a uterus?

Not clearly. Some individual women showed links between progesterone and symptoms, but results overall were not statistically significant. Women don't respond uniformly to hormones.

 Early or limited evidence

9 women with prior hysterectomy and oophorectomy who had severe PMS

## What they did

9 women who had hysterectomy and oophorectomy and previously had severe PMS received estrogen and progesterone in a single-blind study. They completed daily symptom questionnaires and hormone levels were measured.

## What they found

Overall, symptom measures did not correlate with hormone levels. However, individual women sometimes showed correlations between symptom scores and progesterone levels.

## What it means for you

PMS does not respond the same way to hormones in all women. One hormone mechanism cannot explain PMS in everyone. Limitation: very small sample of only 9 women and results were not statistically significant.

9

women studied

## About the study

Original title Can one induce premenstrual symptomatology in women with prior hysterectomy and bilateral oophorectomy? Authors Henshaw C, Foreman D, Belcher J et al. Journal Journal of psychosomatic obstetrics and gynaecology Year 1996 Study design Cohort study What was tested Estrogen and progesterone Read the paper [doi.org/10.3109/01674829609025660](https://doi.org/10.3109/01674829609025660)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Surgical menopause](https://niyora.com/research/topics/treatment-surgery/)

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