---
title: Are hormone levels different between women with menstrually related mood disorder and healthy women?
description: No significant differences were found in hormone levels or patterns between the two groups, suggesting that PMS is not caused by simple hormone deficiency.
url: https://niyora.com/research/papers/changes-in-plasma-hormones-across-the-menstrual-cycle-in-patients-with-1988/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Are hormone levels different between women with menstrually related mood disorder and healthy women?

Case-control study, 1988

# Are hormone levels different between women with menstrually related mood disorder and healthy women?

No significant differences were found in hormone levels or patterns between the two groups, suggesting that PMS is not caused by simple hormone deficiency.

 Early or limited evidence

Women with menstrually related mood disorder and control women (sample size not specified)

## What they did

Blood samples were collected across the menstrual cycle from women with menstrually related mood disorder and control women. Multiple hormones were measured.

## What they found

No differences were observed between groups in levels or patterns of progesterone, estradiol, FSH, LH, testosterone-estradiol-binding globulin, DHEA sulfate, dihydrotestosterone, prolactin, or cortisol.

## What it means for you

PMS does not appear to be caused by abnormal hormone levels alone, which questions some proposed hormone-based treatments. The abstract does not specify the sample size, which is a significant limitation to understanding the study's strength.

2

Diagnostic groups

9

Hormones measured

## About the study

Original title Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects Authors Rubinow DR, Hoban MC, Grover GN et al. Journal American journal of obstetrics and gynecology Year 1988 Study design Case-control study What was tested Hormone measurement across menstrual cycle Read the paper [doi.org/10.1016/0002-9378(88)90765-x](https://doi.org/10.1016/0002-9378(88)90765-x)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Cohort study, 2026

What genetic factors are linked to premenstrual symptoms?

Randomised trial, 2026

Does aerobic or resistance exercise reduce anxiety in women with PMS?

Study, 2026

How do women with PMDD process emotions differently in their brains?

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Case-control study, 2026

Do women with PMS handle emotions differently at different times of the cycle?

Survey study, 2025

Does PMDD or PMS affect quality of life?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗