--- title: Do psychiatric symptoms get worse before the period in women with schizophrenia? description: Yes, overall psychiatric symptoms were worse in the premenstrual phase. However, the psychotic symptoms like hallucinations barely changed, while mood and beh url: https://niyora.com/research/papers/changes-in-premenstrual-symptoms-in-women-with-schizophrenia-a-prospective-study-2001/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do psychiatric symptoms get worse before the period in women with schizophrenia? Cohort study, 2001 # Do psychiatric symptoms get worse before the period in women with schizophrenia? Yes, overall psychiatric symptoms were worse in the premenstrual phase. However, the psychotic symptoms like hallucinations barely changed, while mood and behavioral symptoms worsened significantly. Early or limited evidence 24 women with schizophrenia who completed daily ratings ## What they did Researchers followed 30 female inpatients with schizophrenia for one menstrual cycle. Each woman filled out a daily symptom form every evening. A psychiatrist also rated their symptoms once during each of three menstrual phases using a standard rating scale. ## What they found Of 30 women, 24 completed the daily ratings correctly. The total symptom score was highest in the premenstrual phase and lowest in the postmenstrual phase. Anxiety and depression scores, and withdrawal scores, showed statistically significant differences across the menstrual cycle. Psychotic symptom scores did not change significantly. Depressed mood, anxiety, hostility, and work impairment showed frequent changes in the premenstrual phase. ## What it means for you In women with schizophrenia, premenstrual worsening involves mood, anxiety, and behavior more than the core psychotic symptoms. This suggests premenstrual depression happens alongside schizophrenia as a separate issue. The study is limited by its small size, single-cycle observation, and lack of a control group. 24 women completed the study 3 menstrual phases assessed 30 women who started ## About the study Original title Changes in premenstrual symptoms in women with schizophrenia: a prospective study Authors Choi SH, Kang SB, Joe SH Journal Psychosomatic medicine Year 2001 Study design Cohort study Participants 24 What was tested None Read the paper [doi.org/10.1097/00006842-200109000-00016](https://doi.org/10.1097/00006842-200109000-00016) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2025 How common is PMS in Chinese teenage girls, and what factors are linked to it? Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Survey study, 2025 Can a plant-based supplement reduce PMS symptoms? Review, 2025 How does the menstrual cycle affect psychiatric symptoms like depression and anxiety? Survey study, 2024 What factors are associated with PMS and PMDD in adolescent and young women? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗