--- title: Are hormone rhythms different in women with PMDD, and are they corrected by partial sleep deprivation? description: Women with PMDD had higher prolactin levels and earlier TSH peak timing than normal women. Partial sleep deprivation changed these hormones, but these changes url: https://niyora.com/research/papers/circadian-rhythms-of-prolactin-and-thyroid-stimulating-hormone-during-the-1996/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Are hormone rhythms different in women with PMDD, and are they corrected by partial sleep deprivation? Randomised trial, 1996 # Are hormone rhythms different in women with PMDD, and are they corrected by partial sleep deprivation? Women with PMDD had higher prolactin levels and earlier TSH peak timing than normal women. Partial sleep deprivation changed these hormones, but these changes did not appear to explain how sleep deprivation helped PMDD symptoms. The evidence is moderate but based on a small study. Moderate study design 23 women with PMDD and 18 normal volunteers ## What they did Randomized crossover study. 23 women with PMDD and 18 normal volunteers had blood drawn every 30 minutes from 6pm to 9am during the early and late cycle phases. They then had partial sleep deprivation in separate cycles: sleeping from 3am to 7am (early) or 9pm to 1am (late). ## What they found PMDD women had higher prolactin levels and earlier TSH peak timing than normal women. Sleep deprivation lowered prolactin and raised TSH. Late sleep deprivation shifted prolactin peak timing earlier, and early sleep deprivation shifted it later. However, the researchers found that these hormone changes do not explain why sleep deprivation helps PMDD symptoms. ## What it means for you PMDD involves differences in hormone timing and levels, but sleep deprivation may help through other biological mechanisms not measured by just looking at prolactin and TSH. The study is small and from 1996, so results need confirmation. 23 women with PMDD 18 normal volunteers 30 minutes interval between blood samples ## About the study Original title Circadian rhythms of prolactin and thyroid-stimulating hormone during the menstrual cycle and early versus late sleep deprivation in premenstrual dysphoric disorder Authors Parry BL, Hauger R, LeVeau B et al. Journal Psychiatry research Year 1996 Study design Randomised trial Participants 23 What was tested Early sleep deprivation (3am to 7am) or late sleep deprivation (9pm to 1am) Read the paper [doi.org/10.1016/0165-1781(96)02905-8](https://doi.org/10.1016/0165-1781(96)02905-8) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2024 Do women with PMS or PMDD have disrupted body clocks and sleep? Review, 2024 What do brain wave patterns show about PMS and PMDD? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Cohort study, 2026 What life and psychological factors are linked to PMS and PMDD? Survey study, 2025 Does PMDD affect screen time, sleep quality, and how fast people react? Survey study, 2025 Are premenstrual dysphoric disorder symptoms, stress, and sleep quality linked in female nursing students? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗