---
title: Does troxerutin help with blood vessel problems related to PMS?
description: Yes, according to this double-blind placebo-controlled trial. Women taking high-dose troxerutin showed marked improvement in symptoms within one month, with b
url: https://niyora.com/research/papers/clinical-and-rheological-efficacy-of-troxerutin-in-obstetric-gynecology-1991/
---

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- Does troxerutin help with blood vessel problems related to PMS?

Randomised trial, 1991

# Does troxerutin help with blood vessel problems related to PMS?

Yes, according to this double-blind placebo-controlled trial. Women taking high-dose troxerutin showed marked improvement in symptoms within one month, with benefits lasting through four months of treatment.

 Moderate study design

60 women with enlarged blood vessels in the vulva and leg veins in the context of PMS or pregnancy

## What they did

Double-blind placebo-controlled trial of 60 women with enlarged blood vessels in the vulva and leg veins (half with PMS, half pregnant). Women received either troxerutin or placebo for four months.

## What they found

High-dose troxerutin at 4 g per day was associated with marked improvement in symptoms by the first month. Results were confirmed at four months with excellent patient acceptance and reported improvement.

## What it means for you

Troxerutin may help with blood vessel enlargement in the vulva and leg veins related to PMS, by affecting how thick the blood is. The main limitation is that only half the participants had PMS; the other half were pregnant. The study was published in 1991, so newer research would be valuable.

60

Women in study

4 g per day

Troxerutin dose

4 months

Duration of treatment

## About the study

Original title [Clinical and rheological efficacy of troxerutin in obstetric gynecology] Authors Marhic C Journal Revue francaise de gynecologie et d'obstetrique Year 1991 Study design Randomised trial Participants 60 What was tested High-dose troxerutin at 4 g per day versus placebo Read the paper [https://pubmed.ncbi.nlm.nih.gov/1767176/](https://pubmed.ncbi.nlm.nih.gov/1767176/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

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