---
title: How well do hormone-suppressing drugs work for treating gynaecological conditions?
description: This review suggests that hormone-suppressing drugs called LHRH agonists work well for several gynaecological conditions and have few serious side effects, th
url: https://niyora.com/research/papers/clinical-applications-of-lhrh-analogues-1987/
---

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- How well do hormone-suppressing drugs work for treating gynaecological conditions?

Review, 1987

# How well do hormone-suppressing drugs work for treating gynaecological conditions?

This review suggests that hormone-suppressing drugs called LHRH agonists work well for several gynaecological conditions and have few serious side effects, though larger studies are needed to compare which drugs and doses work best.

 Early or limited evidence

Multiple populations from reviewed studies (specific numbers not stated)

## What they did

A literature review summarizing clinical studies of LHRH agonist and antagonist drugs (which suppress reproductive hormones) for treating various gynaecological conditions.

## What they found

The review reports that LHRH agonists can safely suppress reproductive hormones with quick recovery after stopping. These drugs appear promising for treating precocious puberty, endometriosis, uterine fibroids, polycystic ovary syndrome (PCO), and improving ovulation induction. Nasal administration may work for short-term suppression of up to 28 days. LHRH antagonists were less promising. Combining agonists with other hormone blockers may be even more effective.

## What it means for you

Hormone-suppressing drugs may help with certain gynaecological problems by turning down reproductive hormones, but large-scale studies are still needed to know which drugs and doses work best. These drugs are not specifically studied for PMS or PMDD in this review.

28

Maximum days for nasal hormone-suppressing administration

## About the study

Original title Clinical applications of LHRH analogues Authors Fraser HM, Baird DT Journal Bailliere's clinical endocrinology and metabolism Year 1987 Study design Review What was tested LHRH agonist and antagonist drugs Read the paper [doi.org/10.1016/s0950-351x(87)80052-6](https://doi.org/10.1016/s0950-351x(87)80052-6)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Polycystic ovary syndrome (PCOS)](https://niyora.com/research/topics/comorbidity-pcos/)[Endometriosis](https://niyora.com/research/topics/comorbidity-endometriosis/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/)

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