---
title: Does saffron reduce PMS symptoms? | Niyora
description: Some clinical trials suggest saffron may reduce PMS symptoms more than placebo and similarly to standard treatments, but the evidence comes from a review of s
url: https://niyora.com/research/papers/clinical-applications-of-saffron-crocus-sativus-and-its-constituents-a-review-2015/
---

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- Does saffron reduce PMS symptoms?

Review, 2015

# Does saffron reduce PMS symptoms?

Some clinical trials suggest saffron may reduce PMS symptoms more than placebo and similarly to standard treatments, but the evidence comes from a review of studies rather than new research.

 Early or limited evidence

Women with PMS (from various clinical trials reviewed)

## What they did

Reviewed clinical trials examining saffron's effects on various conditions, including trials in women with PMS.

## What they found

Saffron demonstrated antidepressant effects in 8 clinical trials compared to placebo or standard antidepressant drugs. Two clinical trials on skin care showed saffron was more effective than placebo. Clinical trials in women with PMS showed that saffron reduced suffering symptoms more than placebo and was similar to standard treatments.

## What it means for you

There is some evidence suggesting saffron might help PMS symptoms, but this is a review of existing studies rather than proof from new research. Most evidence focuses on saffron's antidepressant effects. More research is needed to understand how well saffron works specifically for PMS.

8

Antidepressant clinical trials

2

Skin care clinical trials

## About the study

Original title Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review Authors Moshiri M, Vahabzadeh M, Hosseinzadeh H Journal Drug research Year 2015 Study design Review What was tested Saffron Open access Yes Read the paper [doi.org/10.1055/s-0034-1375681](https://doi.org/10.1055/s-0034-1375681)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Saffron](https://niyora.com/research/topics/treatment-saffron/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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Randomised trial, 2020

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Can saffron extract help with PMS or PMDD symptoms?

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Is saffron as effective as fluoxetine for treating PMDD?

Review, 2026

How well do SSRIs treat PMS?

Systematic review, 2026

Does saffron reduce PMS and period pain symptoms?

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