---
title: Which supplement works best for PMS - vitamin E, vitamin B6, calcium, or omega-3?
description: All four supplements and placebo reduced symptom severity over 3 months. The study does not specify which was most effective.
url: https://niyora.com/research/papers/comparison-of-the-effect-of-vit-e-vitb6-calcium-and-omega-3-on-the-treatment-of-2014/
---

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- Which supplement works best for PMS - vitamin E, vitamin B6, calcium, or omega-3?

Randomised trial, 2014

# Which supplement works best for PMS - vitamin E, vitamin B6, calcium, or omega-3?

All four supplements and placebo reduced symptom severity over 3 months. The study does not specify which was most effective.

 Moderate study design

200 women in Iran with moderate-to-severe PMS

## What they did

Double-blind randomized trial. 200 women with moderate-to-severe PMS were divided into 5 groups: calcium, vitamin E, omega-3, vitamin B6, and placebo. They took their supplements for 3 months and tracked symptom changes.

## What they found

All groups, including placebo, showed reduced PMS symptoms in physical, mental, and combined categories. The abstract does not state which supplement worked best or provide specific numbers for individual groups.

## What it means for you

Vitamin E, B6, calcium and omega-3 may all help reduce PMS. However, because placebo also helped, it's unclear how much benefit came from the supplements themselves versus placebo effect or natural improvement. The study does not directly compare the supplements to each other.

200

Total participants

5

Groups tested

3 months

Treatment duration

## About the study

Original title Comparison of the Effect of Vit E, VitB6, Calcium and Omega-3 on the Treatment of Premenstrual Syndrome: A Clinical Randomized Trial Authors Mandana Zafari Journal Annual Research & Review in Biology Year 2014 Study design Randomised trial What was tested Five groups: 1g calcium, 100mg vitamin E, 1g fish oil, 40mg vitamin B6, or placebo daily for 3 months Open access Yes Read the paper [doi.org/10.9734/arrb/2014/7503](https://doi.org/10.9734/arrb/2014/7503)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Omega-3 fatty acids](https://niyora.com/research/topics/treatment-omega-3/)

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