---
title: Do glucose and fructose levels in cervical mucus change during the menstrual cycle?
description: Yes. A small study of 9 women found that glucose and fructose levels in cervical mucus were lower before ovulation than at other cycle phases.
url: https://niyora.com/research/papers/cyclic-changes-in-the-concentration-of-glucose-and-fructose-in-human-cervical-1992/
---

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- Do glucose and fructose levels in cervical mucus change during the menstrual cycle?

Cohort study, 1992

# Do glucose and fructose levels in cervical mucus change during the menstrual cycle?

Yes. A small study of 9 women found that glucose and fructose levels in cervical mucus were lower before ovulation than at other cycle phases.

 Early or limited evidence

9 women with regular menstrual cycles of 28 +/- 3 days

## What they did

9 women with regular menstrual cycles of 28 +/- 3 days had cervical mucus samples collected at three points: before ovulation, after ovulation, and premenstrually. Timing was confirmed with ultrasound and blood hormone measurements.

## What they found

Preovulatory glucose concentrations were lower than postovulatory and premenstrual concentrations. Preovulatory fructose concentrations were lower than premenstrual. Glucose levels correlated with blood progesterone levels.

## What it means for you

Cervical mucus composition changes across the menstrual cycle. This may affect sperm survival or implantation but this is a very small study. The practical relevance to PMS symptoms is unclear.

9

women studied

28 +/- 3

day cycle length

3

cycle phases measured

## About the study

Original title Cyclic changes in the concentration of glucose and fructose in human cervical mucus Authors van der Linden PJ, Kets M, Gimpel JA et al. Journal Fertility and sterility Year 1992 Study design Cohort study What was tested None Open access Yes Read the paper [doi.org/10.1016/s0015-0282(16)54902-4](https://doi.org/10.1016/s0015-0282(16)54902-4)

## Topics

[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)

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