--- title: Do women with major depression or bipolar disorder experience more premenstrual symptoms than healthy women? description: Women with major depression in remission had more PMS than healthy women, with higher scores for depressive mood, anger, and other symptoms. Women with bipola url: https://niyora.com/research/papers/does-menstrual-cycle-affect-bipolar-disorder-patients-or-unipolar-depression-2016/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do women with major depression or bipolar disorder experience more premenstrual symptoms than healthy women? Case-control study, 2016 # Do women with major depression or bipolar disorder experience more premenstrual symptoms than healthy women? Women with major depression in remission had more PMS than healthy women, with higher scores for depressive mood, anger, and other symptoms. Women with bipolar disorder in remission had similar PMS rates to healthy women. Early or limited evidence 23 women with major depression in remission, 23 with bipolar disorder in remission, 23 healthy women ## What they did Compared three groups of 23 women: those with bipolar disorder (in stable mood), those with major depression (in remission), and healthy controls. All completed a questionnaire about premenstrual symptoms. ## What they found PMS was more common in the major depression group than in the control group. Women with depression had higher scores than controls for depressive mood, loss of pleasure, anger, impulsivity, and physical symptoms. The bipolar group had similar PMS rates to the control group. ## What it means for you Women with depression, even when their depression is in remission or being treated, may still experience premenstrual symptoms more than other women. The link may be specific to depression rather than other mood disorders. The main limitation is the small sample size. 23 Women in each group 3 Groups compared ## About the study Original title Does menstrual cycle affect bipolar disorder patients or unipolar depression patients more? Authors Mehmet Yilmaz, Ayşe Devrim Başterzi, Elcin Ozsin et al. Journal Journal of Mood Disorders Year 2016 Study design Case-control study Participants 23 What was tested None Read the paper [doi.org/10.5455/jmood.20161226104246](https://doi.org/10.5455/jmood.20161226104246) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Cohort study, 2022 What are PMS and PMDD and how should they be diagnosed and treated? Cohort study, 2012 How quickly does fluoxetine start working for PMDD symptoms? Review, 1999 Is premenstrual dysphoric disorder a distinct clinical disorder? Survey study, 2022 What factors make PMS mood swings worse? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗