---
title: Does a variation in the estrogen receptor gene affect PMS risk?
description: A specific genetic variant (GG genotype) was 8 times more common in women with severe PMS and 7 times more common in those with edematous PMS, compared to wom
url: https://niyora.com/research/papers/effect-of-estrogen-receptor-gene-esr1-polymorphism-on-development-of-2014/
---

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- Does a variation in the estrogen receptor gene affect PMS risk?

Survey study, 2014

# Does a variation in the estrogen receptor gene affect PMS risk?

A specific genetic variant (GG genotype) was 8 times more common in women with severe PMS and 7 times more common in those with edematous PMS, compared to women without PMS. This was a very small study.

 Early or limited evidence

Women with PMS of various forms and 25 control women without PMS

## What they did

Genetic testing of the A-351G polymorphism of the ESR1 (estrogen receptor) gene in women with various forms of PMS and 25 control women without PMS.

## What they found

Overall, there was no statistically significant difference in this genetic variant between women with and without PMS. However, women with severe PMS had the GG genotype 8.0 times more often than healthy women (p=0.03). Women with edematous form PMS had the GG genotype 7.0 times more often (p=0.05).

## What it means for you

A specific genetic variant may be a marker for more severe forms of PMS. However, this was a very small study looking at only one genetic variation. Much more research is needed to understand the role of genetics in PMS.

8.0

fold increase in GG genotype in severe PMS

7.0

fold increase in GG genotype in edematous PMS

25

control women without PMS

## About the study

Original title Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome Authors Pakharenko L Journal Georgian medical news Year 2014 Study design Survey study Participants 50 What was tested None Open access Yes Read the paper [doi.org/10.30841/2708-8731.1.2020.471239](https://doi.org/10.30841/2708-8731.1.2020.471239) Original abstract

To identify risks of development of any disease is a priority of modern medicine. The aim of this study was to investigate the frequency of polymorphic variants of A-351G gene estrogen receptor ESR1 in patients with various forms of PMS. Molecular genetic analysis of ESR1 gene polymorphism in 50 women with PMS (25 women of them had edematous form of disease, 25 - neuropsychical, 25 - mild, 25 - severe form) was carried out. 25 women without diagnosis of PMS were examined as controls. The study A-351G polymorphism estrogen gene ESR1 showed no statistically significant differences in the frequency of distribution of genotypes and alleles between women with PMS and without this pathology. However, the frequency of GG genotype in women with severe PMS was significantly higher in 8.0 times compared with healthy women (χ2=4.87, p=0.03) and in women with edematous form of PMS - in 7.0 times (χ2=3.72, p=0.05). Thus, a polymorphic variant of A-351G gene ESR1 estrogen can be considered as a marker of PMS. Pathological variant GG genotype was significantly associated with the presence of edematous and severe forms of the disease.

Reproduced under CC-BY.

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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