--- title: Does zinc sulfate help premenstrual syndrome symptoms and quality of life? description: Yes. Zinc sulfate significantly reduced severe PMS over 3 months and improved quality of life, though quality of life benefits took the full 3 months to becom url: https://niyora.com/research/papers/effect-of-zinc-sulfate-supplementation-on-premenstrual-syndrome-and-health-2017/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does zinc sulfate help premenstrual syndrome symptoms and quality of life? Randomised trial, 2017 # Does zinc sulfate help premenstrual syndrome symptoms and quality of life? Yes. Zinc sulfate significantly reduced severe PMS over 3 months and improved quality of life, though quality of life benefits took the full 3 months to become statistically significant. Moderate study design 142 women aged 20-35 with premenstrual syndrome ## What they did A double-blind randomized controlled trial with 142 women aged 20-35 with PMS from June 2013 to May 2014. Women received either zinc sulfate 220 mg (containing 50 mg elemental zinc) or placebo taken from day 16 of the menstrual cycle to day 2 of the next cycle. Symptoms and quality of life were measured using standard questionnaires. ## What they found In the zinc group, moderate to severe PMS decreased from 9.5% in the first month to 2.6% in the third month (P < 0.001). In the placebo group, it decreased slightly from 14.2% to 13.5% (P = 0.08, not statistically significant). Zinc improved symptom scores throughout the study, and quality of life improved significantly at 3 months. ## What it means for you Zinc sulfate may help reduce PMS symptoms and improve quality of life. It is simple and inexpensive. However, the study lasted only 3 months and larger or longer studies are needed to confirm these findings. 142 women studied 50 mg elemental zinc per dose 2.6% severe PMS at month 3 in zinc group ## About the study Original title Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial Authors Siahbazi S, Behboudi-Gandevani S, Moghaddam-Banaem L et al. Journal The journal of obstetrics and gynaecology research Year 2017 Study design Randomised trial Participants 142 What was tested Zinc sulfate 220 mg (50 mg elemental zinc) from day 16 to day 2 of next cycle Read the paper [doi.org/10.1111/jog.13299](https://doi.org/10.1111/jog.13299) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Zinc and iron](https://niyora.com/research/topics/treatment-zinc-iron/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2020 Does zinc supplementation improve quality of life and sleep in young women with PMS? Survey study, 2026 Can changing your diet help with period and PMS symptoms like fatigue, mood swings and bloating? Survey study, 2021 Does iron status affect the risk of PMS symptoms? Cohort study, 2026 Is PMS becoming more common and more disabling worldwide? Randomised trial, 2026 Does yoga or Pilates help reduce PMS symptoms? Randomised trial, 2026 Does Kundalini Reiki help reduce PMS symptoms and improve quality of life? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗