---
title: Does venlafaxine help women with PMDD? | Niyora
description: Yes. This small study found venlafaxine significantly improved PMDD symptoms in Asian women.
url: https://niyora.com/research/papers/effective-open-label-treatment-of-premenstrual-dysphoric-disorder-with-2003/
---

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- Does venlafaxine help women with PMDD?

Non-randomised trial, 2003

# Does venlafaxine help women with PMDD?

Yes. This small study found venlafaxine significantly improved PMDD symptoms in Asian women.

 Early or limited evidence

30 Asian women with PMDD (20 completed)

## What they did

Thirty women with PMDD were treated with flexible-dose venlafaxine for two menstrual cycles. Symptom severity was assessed every 2 weeks using multiple rating scales.

## What they found

Twenty women completed the trial. All participants showed significant improvement in mood and behavior symptoms. Venlafaxine at mean dose 60.1 +/- 29.1 mg per day was effective.

## What it means for you

Venlafaxine may help PMDD symptoms, though this was a small, uncontrolled study without a placebo group to confirm the effect was due to the medication.

30

women with PMDD enrolled

20

women completed treatment

60.1

mean dose venlafaxine (mg per day)

## About the study

Original title Effective open-label treatment of premenstrual dysphoric disorder with venlafaxine Authors Hsiao MC, Liu CY Journal Psychiatry and clinical neurosciences Year 2003 Study design Non-randomised trial What was tested Venlafaxine at flexible dosing for two menstrual cycles Open access Yes Read the paper [doi.org/10.1046/j.1440-1819.2003.01123.x](https://doi.org/10.1046/j.1440-1819.2003.01123.x)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2008

What treatments work best for PMS and PMDD?

Randomised trial, 2003

Are SSRI antidepressants effective for PMDD?

Randomised trial, 1999

Do SSRIs reduce premenstrual dysphoria symptoms?

Randomised trial, 1995

Does fluoxetine help premenstrual dysphoria?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Cohort study, 2019

Do SSRIs help women who have both PMS and panic disorder?

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