---
title: Is Jiawei Xiaoyao pill effective and safe for treating premenstrual syndrome?
description: Yes, women who took Jiawei Xiaoyao pill experienced significantly greater reduction in PMS symptoms than those taking placebo (p=0.002 and p=0.001), with no s
url: https://niyora.com/research/papers/effectiveness-and-safety-of-jiawei-xiaoyao-pill-in-the-treatment-of-premenstrual-2024/
---

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- Is Jiawei Xiaoyao pill effective and safe for treating premenstrual syndrome?

Randomised trial, 2024

# Is Jiawei Xiaoyao pill effective and safe for treating premenstrual syndrome?

Yes, women who took Jiawei Xiaoyao pill experienced significantly greater reduction in PMS symptoms than those taking placebo (p=0.002 and p=0.001), with no serious side effects reported.

 Strong study design

144 regularly menstruating women with premenstrual syndrome in China

## What they did

Randomized controlled trial at 8 sites in China from August 2017 to December 2018. 144 women with regular periods and PMS complaints were randomly assigned to receive either Jiawei Xiaoyao pill or placebo (12 grams daily, 6 grams twice a day) for 3 menstrual cycles.

## What they found

The pill group showed greater reduction in DRSP scores (which measure psychological and physical symptoms during the luteal phase) compared to placebo (p=0.002 for one measure, p=0.001 for another). There were no significant differences in adverse events between the two groups.

## What it means for you

This Chinese herbal medicine may reduce PMS symptoms safely. The study was done only in China and focused on one specific type of PMS pattern, so results may not apply to all women or other countries.

144

total participants

3

menstrual cycles of treatment

0.002

p-value for symptom reduction

## About the study

Original title Effectiveness and safety of Jiawei Xiaoyao pill in the treatment of premenstrual syndrome (liver depression, spleen deficiency, and blood-heat syndrome): a multi-center, randomized, placebo-controlled trial Authors Xiyu LI, Yanhong Y, Jian S et al. Journal Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Year 2024 Study design Randomised trial Participants 144 What was tested Jiawei Xiaoyao pill 12 grams daily (6 grams twice daily) or matching placebo for 3 menstrual cycles Open access Yes Read the paper [doi.org/10.19852/j.cnki.jtcm.20231110.003](https://doi.org/10.19852/j.cnki.jtcm.20231110.003)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)

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