---
title: Does vitamin B6 help with premenstrual syndrome? | Niyora
description: Yes, a meta-analysis of 6 controlled trials found that vitamin B6 is effective for treating PMS.
url: https://niyora.com/research/papers/effectiveness-of-pyridoxine-in-the-treatment-of-premenstrual-syndrome-meta-2003/
---

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- Does vitamin B6 help with premenstrual syndrome?

Systematic review, 2003

# Does vitamin B6 help with premenstrual syndrome?

Yes, a meta-analysis of 6 controlled trials found that vitamin B6 is effective for treating PMS.

 Moderate study design

Women with PMS (from 6 controlled trials)

## What they did

Meta-analysis of 6 controlled clinical trials testing pyridoxine (vitamin B6) for PMS symptoms.

## What they found

Results were divided into two categories. Category 1 showed relative risk of 1.18 with 95% confidence interval 1.06 to 1.30. Category 2 showed relative risk of 3.34 with 95% confidence interval 2.12 to 5.25. Both showed pyridoxine was more effective than control treatment.

## What it means for you

Vitamin B6 appears to help PMS symptoms. However, this analysis is from 2003 and includes only 6 trials, which is a small amount of evidence. The abstract does not explain what Category 1 and Category 2 represent, which makes it difficult to understand what these results mean in practice.

6

controlled trials analyzed

1.18

relative risk Category 1 (95% CI 1.06-1.30)

3.34

relative risk Category 2 (95% CI 2.12-5.25)

## About the study

Original title Effectiveness of Pyridoxine in the Treatment of Premenstrual Syndrome: Meta-analysis of Controlled Trials Authors Long-Yan Lin, Li‐Hsing Ho, Ching‐Yi Lin Journal 中山醫學雜誌 Year 2003 Study design Systematic review What was tested Pyridoxine (vitamin B6) Read the paper [doi.org/10.30096/csmj.200301.0006](https://doi.org/10.30096/csmj.200301.0006)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)

Research tells you what helps on average. Niyora helps on the day it hits.

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