---
title: Do magnesium or vitamin B6 reduce premenstrual syndrome severity?
description: Both magnesium and vitamin B6 significantly reduced PMS symptoms more than placebo, with B6 being most effective.
url: https://niyora.com/research/papers/effects-of-magnesium-and-vitamin-b6-on-the-severity-of-premenstrual-syndrome-2012/
---

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- Do magnesium or vitamin B6 reduce premenstrual syndrome severity?

Randomised trial, 2012

# Do magnesium or vitamin B6 reduce premenstrual syndrome severity?

Both magnesium and vitamin B6 significantly reduced PMS symptoms more than placebo, with B6 being most effective.

 Moderate study design

126 women with premenstrual syndrome in Iran

## What they did

A double-blind randomized controlled trial of 126 women divided equally into 3 groups. Women first kept menstrual diaries for 2 months. Then one group received magnesium, one received vitamin B6 and one received placebo for 2 menstrual cycles. Symptoms before and after treatment were compared.

## What they found

Mean PMS scores significantly decreased after intervention in all three groups. Vitamin B6 had the most efficiency in improving PMS scores while placebo had the least.

## What it means for you

Vitamin B6 and magnesium both reduce PMS severity better than placebo, with B6 being the most effective. This was a well-designed blinded controlled trial. The study was done in Iran, so results may not apply to all populations.

126

women

2

months baseline diary

2

cycles of treatment

## About the study

Original title Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms Authors Ebrahimi E, Khayati Motlagh S, Nemati S et al. Journal Journal of caring sciences Year 2012 Study design Randomised trial Participants 126 What was tested Magnesium, vitamin B6 or placebo for 2 menstrual cycles Open access Yes Read the paper [doi.org/10.5681/jcs.2012.026](https://doi.org/10.5681/jcs.2012.026)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)

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