--- title: Does menstrual cycle phase affect how women respond to triazolam? description: No. The effects of triazolam on mood and performance were stable across all three phases of the menstrual cycle. url: https://niyora.com/research/papers/effects-of-triazolam-at-three-phases-of-the-menstrual-cycle-1999/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does menstrual cycle phase affect how women respond to triazolam? Randomised trial, 1999 # Does menstrual cycle phase affect how women respond to triazolam? No. The effects of triazolam on mood and performance were stable across all three phases of the menstrual cycle. Moderate study design 20 healthy women ## What they did Twenty healthy women received either triazolam 0.25 mg or placebo at three different phases of their menstrual cycles in a crossover study. Researchers measured mood, arousal, psychomotor performance, and hormone and drug levels in the blood. ## What they found Most women reported the expected increases in fatigue and decreases in alertness and psychomotor performance after triazolam at all three cycle phases. Neither blood levels of triazolam nor mood and performance effects differed across follicular, ovulatory, and luteal phases. ## What it means for you Menstrual cycle hormones do not substantially change how this sleep medication affects mood and performance. The main limit is the small sample size and that all women were healthy, not people with anxiety or sleep problems. 20 Women studied 3 Menstrual cycle phases tested 0.25 mg Triazolam dose ## About the study Original title Effects of triazolam at three phases of the menstrual cycle Authors Rukstalis M, de Wit H Journal Journal of clinical psychopharmacology Year 1999 Study design Randomised trial What was tested Triazolam 0.25 mg oral dose or placebo Read the paper [doi.org/10.1097/00004714-199910000-00009](https://doi.org/10.1097/00004714-199910000-00009) ## Topics [Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Fatigue and energy](https://niyora.com/research/topics/symptom-fatigue/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Case-control study, 2015 Does lamotrigine reduce menstrual cycle-related mood changes in women with bipolar disorder? Review, 2006 How do brain hormones affect PMDD and mood problems during the menstrual cycle? Survey study, 2026 Does PMS affect how well young women sleep? Case-control study, 2016 Do women with PMDD respond differently to allopregnanolone across the menstrual cycle? Survey study, 2014 Does allopregnanolone, a progesterone metabolite, cause mood problems in PMDD? Survey study, 2011 Why do some women experience negative mood with hormone changes? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗