--- title: Does weight loss medication with diet help overweight women lose weight and improve gynecological symptoms? description: Among women who completed 3 months of treatment with dexfenfluramine and diet, 80% lost weight with an average loss of 7.2 kg. Younger women also reported imp url: https://niyora.com/research/papers/efficacy-and-acceptability-of-dexfenfluramine-in-women-consulting-in-gynecology-1992/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does weight loss medication with diet help overweight women lose weight and improve gynecological symptoms? Study, 1992 # Does weight loss medication with diet help overweight women lose weight and improve gynecological symptoms? Among women who completed 3 months of treatment with dexfenfluramine and diet, 80% lost weight with an average loss of 7.2 kg. Younger women also reported improvement in premenstrual symptoms. Moderate study design 336 overweight women (80% in reproductive years, 20% perimenopausal or post-menopausal), followed by gynecologists ## What they did Treated 336 overweight women with dexfenfluramine combined with prescribed diet for 3 months. Women were grouped by age: 80% in reproductive years and 20% perimenopausal or post-menopausal. Researchers measured weight loss and tracked changes in gynecological symptoms. ## What they found 80% of women who completed the 3-month treatment lost weight, with a mean loss of 7.2 kg, which represented 41.9% of their initial excess weight. Women in reproductive years reported improvement in premenstrual symptoms. Women in perimenopausal and post-menopausal groups reported improvement in menopause-related symptoms. ## What it means for you A weight loss medication combined with diet can help overweight women lose significant weight and may improve premenstrual symptoms. The main limitations are that the study only lasted 3 months, included only women who completed the full treatment, and had no comparison group not taking the medication, so we cannot be certain the medication itself caused the improvements. 336 Women studied 80% Who lost weight after completing treatment 7.2 kg Average weight loss ## About the study Original title [Efficacy and acceptability of dexfenfluramine in women consulting in gynecology. 336 overweight patients treated for 3 months] Authors Elia D, Auclair J, Rey C Journal Revue francaise de gynecologie et d'obstetrique Year 1992 Study design Study Participants 336 What was tested Dexfenfluramine combined with prescribed diet for 3 months Read the paper [https://pubmed.ncbi.nlm.nih.gov/1631479/](https://pubmed.ncbi.nlm.nih.gov/1631479/) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2026 Why do some women experience mood changes linked to their menstrual cycle? Guideline, 2024 How should Xiangshao Granules be prescribed for premenstrual tension syndrome? Systematic review, 2023 Does saffron help with PMS, labor pain, and menopause symptoms? Cohort study, 2023 Do women with premenstrual disorders go through menopause earlier and have worse hot flashes? Review, 2018 Which women are most likely to experience hot flashes during menopause? Review, 2017 Can combining different types of treatments help PMS more than using one approach alone? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗