--- title: Is Ganyushu Granule effective and safe for premenstrual syndrome? description: Yes, both high-dose and low-dose Ganyushu Granule reduced PMS symptoms better than placebo starting from the second cycle, with high-dose showing the fastest url: https://niyora.com/research/papers/efficacy-and-safety-of-ganyushu-granule-in-treatment-of-premenstrual-syndrome-2024/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Is Ganyushu Granule effective and safe for premenstrual syndrome? Randomised trial, 2024 # Is Ganyushu Granule effective and safe for premenstrual syndrome? Yes, both high-dose and low-dose Ganyushu Granule reduced PMS symptoms better than placebo starting from the second cycle, with high-dose showing the fastest improvement and no serious side effects. Strong study design 240 women with premenstrual syndrome and liver depression/qi stagnation in China ## What they did Randomized controlled trial from June 2018 to March 2021 with 240 women with PMS and liver depression/qi stagnation. Women were divided into three groups: high-dose Ganyushu Granule (78 women), low-dose Ganyushu Granule (82 women), and placebo (80 women). Treatment was taken 3 times daily for up to 3 menstrual cycles. ## What they found Starting from the 2nd cycle, both high and low-dose groups had lower PMS diary scores than placebo (P<0.05). The high-dose group had lower tension scores after the 1st cycle and the best Chinese medicine syndrome improvement after the 2nd cycle. No serious adverse reactions were reported in any group. ## What it means for you Ganyushu Granule appears to safely reduce PMS symptoms, with higher doses working faster. The study was conducted only in China for one specific PMS pattern, so results may not apply to all women or other countries. 240 total participants 3 treatment groups 3 menstrual cycles ## About the study Original title Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan (Liver) Depression and Qi Stagnation Syndrome: A Randomized, Double-Blind, Multicenter, Phase-II Clinical Trial Authors Teng XX, Xu LW, Lin J et al. Journal Chinese journal of integrative medicine Year 2024 Study design Randomised trial Participants 240 What was tested High-dose or low-dose Ganyushu Granule or placebo, 3 times daily for up to 3 menstrual cycles Read the paper [doi.org/10.1007/s11655-024-3755-z](https://doi.org/10.1007/s11655-024-3755-z) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2024 Is Jiawei Xiaoyao pill effective and safe for treating premenstrual syndrome? Systematic review, 2023 Does saffron help with PMS, labor pain, and menopause symptoms? Review, 2017 Can combining different types of treatments help PMS more than using one approach alone? Systematic review, 2017 Is Vitex agnus castus safe and effective for treating PMS and PMDD? Review, 2015 What treatments work best for PMDD and PMS? Review, 2015 What do we know about PMS and PMDD and how are they treated? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗