---
title: Does a flavonoid supplement help with premenstrual leg heaviness?
description: Yes. In women with premenstrual leg heaviness, taking a flavonoid supplement daily for 15 days during the second half of the menstrual cycle for 3 months redu
url: https://niyora.com/research/papers/efficacy-of-medicamentous-treatment-of-transient-premenstrual-phlebopathy-of-2020/
---

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- Does a flavonoid supplement help with premenstrual leg heaviness?

Study, 2020

# Does a flavonoid supplement help with premenstrual leg heaviness?

Yes. In women with premenstrual leg heaviness, taking a flavonoid supplement daily for 15 days during the second half of the menstrual cycle for 3 months reduced heaviness in most women and decreased swelling.

 Early or limited evidence

39 parous women (mean age 31.3 years) who had premenstrual leg heaviness and swelling

## What they did

39 women with premenstrual leg heaviness were examined before and after 3 months of treatment with a daily flavonoid supplement. Measurements were taken during the menstrual phase and the secretory phase of the cycle.

## What they found

Leg heaviness decreased from 39 women to 4 women (14.3%). In 85.3% of women the leg heaviness was completely removed. Swelling decreased significantly. The enlarged veins returned to smaller sizes. All women had no morning vein problems after treatment and evening vein problems occurred in only 6 women (15.4%).

## What it means for you

A flavonoid supplement taken for 15 days each cycle over 3 months may help premenstrual leg heaviness and swelling by reducing vein enlargement. The main limits are that only 39 women were studied and there was no comparison group of women who did not take the supplement.

85.3%

women with complete removal of leg heaviness

1000 mg

daily dose of flavonoid supplement

4 (14.3%)

women still having leg heaviness after 3 months

## About the study

Original title [Efficacy of medicamentous treatment of transient premenstrual phlebopathy of lower limbs] Authors Tsukanov IT, Nikolaĭchuk AI, Nikolaĭchuk TV Journal Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery Year 2020 Study design Study Participants 39 What was tested Flavonoid supplement, 1000 mg daily, in 15-day courses during the second half of the menstrual cycle for 3 months Read the paper [doi.org/10.33529/angio2020118](https://doi.org/10.33529/angio2020118)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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