--- title: Does stopping ovulation with danazol help severe PMS? | Niyora description: Yes. When women took danazol and stopped ovulating, 20 out of 23 cycles had no symptoms, compared to 6 out of 32 cycles when they were still ovulating. This s url: https://niyora.com/research/papers/elimination-of-ovulation-and-menstrual-cyclicity-with-danazol-improves-dysphoric-1991/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does stopping ovulation with danazol help severe PMS? Study, 1991 # Does stopping ovulation with danazol help severe PMS? Yes. When women took danazol and stopped ovulating, 20 out of 23 cycles had no symptoms, compared to 6 out of 32 cycles when they were still ovulating. This shows a clear difference. Moderate study design 24 women with severe dysphoric PMS ## What they did Twenty-four women with severe dysphoric PMS first took a placebo for one month. Then they took 200 mg of danazol daily for 90 days. They recorded their symptoms every day using a standard form before, during, and after treatment. Researchers compared their symptoms during months when they weren't ovulating to months when they were ovulating. ## What they found During periods when women were not ovulating, 20 out of 23 cycles had no symptoms. During periods when they were still ovulating, only 6 out of 32 cycles had no symptoms. The benefit of danazol appeared to come from stopping ovulation and hormonal cycling, not from the drug itself. ## What it means for you Danazol helps severe PMS mainly by stopping the hormonal cycle. This suggests that interrupting hormone cycling is effective. The main limits are that this was a relatively small study and it doesn't tell us how long benefits last after stopping the drug or whether it works for milder PMS. 24 women studied 200 mg danazol daily dose 20 of 23 anovulatory cycles symptom-free ## About the study Original title Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes Authors Halbreich U, Rojansky N, Palter S Journal Fertility and sterility Year 1991 Study design Study Participants 24 What was tested 200 mg daily danazol for 90 days Open access Yes Read the paper [doi.org/10.1016/s0015-0282(16)54718-9](https://doi.org/10.1016/s0015-0282(16)54718-9) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2024 What are the best treatments for PMDD and PMS? Guideline, 2023 How are GnRH agonists used to treat PMDD that doesn't respond to standard medications? Review, 2022 What causes severe PMS and what treatments work? Systematic review, 2022 What are the best treatments for PMDD and PMS? Review, 2018 What are the most effective treatments for premenstrual syndrome and PMDD? Review, 2018 Which women are most likely to experience hot flashes during menopause? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗