---
title: Do women with rheumatoid arthritis have more PMDD? | Niyora
description: Yes. Women with rheumatoid arthritis are 4.54 times more likely to have PMDD (24% vs 6%) and 4.9 times more likely to experience functional impairment from PM
url: https://niyora.com/research/papers/evaluating-premenstrual-dysphoric-disorder-in-women-with-rheumatoid-arthritis-2025/
---

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- Do women with rheumatoid arthritis have more PMDD?

Case-control study, 2025

# Do women with rheumatoid arthritis have more PMDD?

Yes. Women with rheumatoid arthritis are 4.54 times more likely to have PMDD (24% vs 6%) and 4.9 times more likely to experience functional impairment from PMDD compared to healthy women.

 Moderate study design

67 women with rheumatoid arthritis and 67 healthy controls in Mexico, mean age 39.8

## What they did

Cross-sectional study comparing 67 women with rheumatoid arthritis to 67 healthy women in Mexico, matched by age (mean 39.8 years). Used a screening tool to assess for PMDD and its impact on daily functioning.

## What they found

PMDD was present in 24% of RA patients (15 women) versus 6% of controls (4 women). Functional impairment from PMDD was more common in RA patients (28.4%, 19 women) than controls (7.5%, 4 women). Women with RA had 4.54 times higher odds of PMDD and 4.9 times higher odds of functional impairment.

## What it means for you

The inflammation from rheumatoid arthritis may increase PMDD risk or severity. This is one study from one center in Mexico, so results may not apply to all populations. More research is needed.

24%

PMDD in RA women vs 6% controls

4.54

Odds ratio for PMDD

28.4%

Functional impairment in RA

## About the study

Original title Evaluating Premenstrual Dysphoric Disorder in Women With Rheumatoid Arthritis and Healthy Female Subjects Authors Bardan-Inchaustegui AC, Colunga-Pedraza IJ, Elizondo-Benitez MF et al. Journal Musculoskeletal care Year 2025 Study design Case-control study Participants 19 What was tested None - observational study Open access Yes Read the paper [doi.org/10.1002/msc.70106](https://doi.org/10.1002/msc.70106)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/)

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