---
title: Do GnRH agonist drugs treat PMS? | Niyora
description: Yes, GnRH agonist drugs can completely abolish PMS symptoms. However, they cause significant side effects from lowered estrogen that can be managed with add-b
url: https://niyora.com/research/papers/gonadotrophin-receptor-hormone-analogues-in-combination-with-add-back-therapy-an-2012/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Do GnRH agonist drugs treat PMS?

Review, 2012

# Do GnRH agonist drugs treat PMS?

Yes, GnRH agonist drugs can completely abolish PMS symptoms. However, they cause significant side effects from lowered estrogen that can be managed with add-back therapy.

 Early or limited evidence

Women with PMS, endometriosis, and fibroids

## What they did

Review article updating evidence on GnRH agonists combined with add-back therapy for treating PMS and other hormone-dependent conditions.

## What they found

GnRH agonists can completely abolish PMS symptoms. They are also effective for endometriosis and as adjuvant therapy for fibroids. Side effects from the low-estrogen state limited their previous use, but add-back therapy allows for wider application, longer treatment duration, and better patient compliance.

## What it means for you

GnRH agonist drugs can eliminate PMS symptoms but cause significant side effects from low estrogen. Add-back therapy helps manage these side effects. This is a review of existing evidence rather than new research, and the abstract does not provide specific outcome details.

## About the study

Original title Gonadotrophin receptor hormone analogues in combination with add-back therapy: an update Authors McLaren JS, Morris E, Rymer J Journal Menopause international Year 2012 Study design Review What was tested GnRH agonist drugs combined with add-back therapy Read the paper [doi.org/10.1258/mi.2012.012008](https://doi.org/10.1258/mi.2012.012008)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Endometriosis](https://niyora.com/research/topics/comorbidity-endometriosis/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Review, 2012

How can doctors manage premenstrual-like symptoms caused by hormonal treatments containing progestogen?

Non-randomised trial, 2002

Is it safe to use hormone therapy alongside GnRH-agonist treatment for severe PMS?

Randomised trial, 1996

Does hormone replacement therapy prevent low-estrogen side effects of GnRH agonist treatment for severe PMS?

Systematic review, 2023

What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy?

Randomised trial, 2012

Do hysterectomy or hormonal IUDs reduce premenstrual symptoms in women with heavy periods?

Randomised trial, 2009

Is dydrogesterone or calcium plus vitamin D better for severe PMS?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗