---
title: Does cycle-related anger connect to depression? | Niyora
description: In a rat study, females showing more anger during certain parts of their cycle also showed depression-like behavior at the same stage, suggesting these traits
url: https://niyora.com/research/papers/increased-depressive-like-traits-in-an-animal-model-of-premenstrual-irritability-2007/
---

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- Does cycle-related anger connect to depression?

Survey study, 2007

# Does cycle-related anger connect to depression?

In a rat study, females showing more anger during certain parts of their cycle also showed depression-like behavior at the same stage, suggesting these traits may share similar biological roots.

 Early or limited evidence

Female Wistar rats (sample size not stated)

## What they did

Researchers tested female Wistar rats at different points in their menstrual-like cycle for aggression, anxiety, depression-like behavior, and food preferences. They used behavior tests to measure aggression, anxiety in a maze, and depression-like traits by watching swimming behavior.

## What they found

Rats that showed aggression related to their cycle spent more time immobile and less time swimming during one cycle phase compared to another, showing depression-like behavior. Rats without cycle-related aggression did not show this pattern. Anxiety, activity level, stress response, and sugar preference were the same between aggressive and non-aggressive rats.

## What it means for you

This animal study suggests that cycle-related anger and depression-like traits may share the same biological cause. This could help explain why some women with PMDD experience both anger and mood changes. However, results from rats don't tell us directly how this works in women's brains or which brain chemicals are involved.

Wistar rats

Study organism

Anger + mood

Trait link

Cycle linked

Pattern found

## About the study

Original title Increased depressive-like traits in an animal model of premenstrual irritability Authors Schneider T, Popik P Journal Hormones and behavior Year 2007 Study design Survey study What was tested None - observation at different cycle phases Read the paper [doi.org/10.1016/j.yhbeh.2006.09.006](https://doi.org/10.1016/j.yhbeh.2006.09.006)

## Topics

[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Stress](https://niyora.com/research/topics/symptom-stress/)

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