---
title: Does stopping ovulation with buserelin help premenstrual tension syndrome?
description: Yes, buserelin (which stops ovulation) worked significantly better than placebo and eliminated the monthly symptom pattern. This shows the menstrual cycle is
url: https://niyora.com/research/papers/induced-anovulation-as-treatment-of-premenstrual-tension-syndrome-a-double-blind-1988/
---

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- Does stopping ovulation with buserelin help premenstrual tension syndrome?

Randomised trial, 1988

# Does stopping ovulation with buserelin help premenstrual tension syndrome?

Yes, buserelin (which stops ovulation) worked significantly better than placebo and eliminated the monthly symptom pattern. This shows the menstrual cycle is the cause of these symptoms.

 Moderate study design

26 women with premenstrual tension syndrome (23 completed)

## What they did

26 women with PMS received buserelin nasal spray (400 micrograms once daily) or placebo in a double-blind crossover design. 23 women completed the study. Women rated their symptoms daily for 2 baseline cycles, then for up to 6 treatment cycles or 6 months. Blood samples for hormone levels were taken weekly.

## What they found

Both placebo and buserelin were better than the woman's own baseline symptoms. Buserelin was significantly better than placebo. Women on placebo still had symptoms that changed monthly at the end of treatment, but women taking buserelin no longer had this monthly pattern.

## What it means for you

Stopping ovulation clearly helps PMS and eliminates the monthly pattern of symptoms. Small study with 26 women. The study proves the menstrual cycle is involved in causing these symptoms.

26

women enrolled (23 completed)

400 micrograms

buserelin dose daily

6 months

study duration

## About the study

Original title Induced anovulation as treatment of premenstrual tension syndrome. A double-blind cross-over study with GnRH-agonist versus placebo Authors Hammarbäck S, Bäckström T Journal Acta obstetricia et gynecologica Scandinavica Year 1988 Study design Randomised trial Participants 26 What was tested GnRH-agonist buserelin nasal spray 400 micrograms daily versus placebo Read the paper [doi.org/10.3109/00016348809004191](https://doi.org/10.3109/00016348809004191)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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Does stopping ovulation help severe premenstrual tension?

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