---
title: What treatments help when PMS becomes very severe? | Niyora
description: Several treatments can help severe PMS, including antidepressants, anxiety medications, and hormones that stop ovulation. The right choice depends on each wom
url: https://niyora.com/research/papers/interactive-case-challenge-dysphoric-disorders-in-women-a-case-of-premenstrual-1998/
---

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- What treatments help when PMS becomes very severe?

Case report, 1998

# What treatments help when PMS becomes very severe?

Several treatments can help severe PMS, including antidepressants, anxiety medications, and hormones that stop ovulation. The right choice depends on each woman's specific symptoms.

 Early or limited evidence

36-year-old woman with severe PMS and three children under age 10.

## What they did

Case discussion of a woman whose PMS grew progressively worse over 3 years after having her third child.

## What they found

Severe PMS can be treated with several options. These include antidepressants, anxiety medications, and hormones that suppress ovulation. Symptoms that respond to treatment include mood swings, irritability and anxiety.

## What it means for you

Multiple treatment options exist for severe PMS that interferes with daily life. The main limit is that this is a single case discussion, not evidence from a large study testing which treatment works best.

3

number of children

36

age of woman in case

3

years PMS worsened over after third child born

## About the study

Original title Interactive case challenge. Dysphoric disorders in women: a case of premenstrual syndrome Authors Pearlstein T, Jain N, Zlotnick C et al. Journal Medscape women's health Year 1998 Study design Case report What was tested Various pharmacologic and nonpharmacologic treatments discussed. Read the paper [https://pubmed.ncbi.nlm.nih.gov/9802916/](https://pubmed.ncbi.nlm.nih.gov/9802916/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Randomised trial, 1995

Does fluoxetine help premenstrual dysphoria?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Randomised trial, 2017

Does Sepranolone reduce symptoms of severe premenstrual syndrome (PMDD)?

Cohort study, 2012

How quickly does fluoxetine start working for PMDD symptoms?

Review, 2003

What is PMDD and what treats it?

Review, 1999

Is premenstrual dysphoric disorder a distinct clinical disorder?

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