---
title: Does taking nefazodone just during the luteal phase help PMDD?
description: Yes. All three women who took nefazodone reported marked improvement in symptoms. All three had complete relief of emotional symptoms, and two also had comple
url: https://niyora.com/research/papers/intermittent-luteal-phase-nefazodone-treatment-of-premenstrual-dysphoric-2001/
---

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- Does taking nefazodone just during the luteal phase help PMDD?

Case report, 2001

# Does taking nefazodone just during the luteal phase help PMDD?

Yes. All three women who took nefazodone reported marked improvement in symptoms. All three had complete relief of emotional symptoms, and two also had complete relief of body symptoms. This is a very small study.

 Early or limited evidence

3 women with PMDD

## What they did

Three women with PMDD took nefazodone at 50 mg twice a day for 2 weeks during the luteal phase of their menstrual cycle only.

## What they found

All three reported marked improvement in symptoms. All three had full remission of emotional symptoms. Two also had full remission of body symptoms. Side effects were mild.

## What it means for you

Taking PMDD medication only during the luteal phase might work well and cause fewer side effects than taking it every day. It might also help women stick with treatment better. The main limit is that only three women were studied.

3

women studied

100 mg/day

total daily dose of nefazodone

2

weeks of treatment

## About the study

Original title Intermittent, luteal phase nefazodone treatment of premenstrual dysphoric disorder Authors Kodesh A, Katz S, Lerner AG et al. Journal Journal of psychopharmacology (Oxford, England) Year 2001 Study design Case report What was tested Nefazodone 50 mg twice a day for 2 weeks during the luteal phase Read the paper [doi.org/10.1177/026988110101500110](https://doi.org/10.1177/026988110101500110)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Cohort study, 2026

What genetic factors are linked to premenstrual symptoms?

Systematic review, 2026

How often do mood disorders and PMS or PMDD occur together?

Systematic review, 2026

Does vitamin D supplementation help PMS symptoms?

Study, 2026

How do women with PMDD process emotions differently in their brains?

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Systematic review, 2026

How much of PMDD treatment improvement comes from placebo effect?

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