---
title: Does hormone desensitization help PMS and improve pregnancy outcomes in women with recurrent miscarriage?
description: Yes, 21 of 26 women had improved PMS symptoms and 61% had successful pregnancies afterward. This is a very small study with no control group, so we cannot be
url: https://niyora.com/research/papers/intradermal-sex-hormone-desensitization-for-relief-of-premenstrual-symptoms-may-2013/
---

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- Does hormone desensitization help PMS and improve pregnancy outcomes in women with recurrent miscarriage?

Non-randomised trial, 2013

# Does hormone desensitization help PMS and improve pregnancy outcomes in women with recurrent miscarriage?

Yes, 21 of 26 women had improved PMS symptoms and 61% had successful pregnancies afterward. This is a very small study with no control group, so we cannot be confident this works.

 Early or limited evidence

26 women aged 25-42 with repeated pregnancy loss (3-8 previous miscarriages), PMS, and allergic reactions to sex hormones on skin testing

## What they did

A 10-year open-label study of 26 women aged 25-42 with 3-8 previous miscarriages, current PMS, and who tested positive for allergic reactions to sex hormones on skin testing. They received small injections of hormones under the skin to desensitize them to estrogen and/or progesterone. Researchers tracked their PMS symptoms and pregnancy outcomes.

## What they found

After treatment, 21 of 26 women had improvement in PMS symptoms that was stable long-term. In subsequent pregnancies, 16 of 26 women (61%) had live births. Five women had two successful pregnancies. No obstetric complications were reported.

## What it means for you

Hormone desensitization may help severe PMS in some women and might improve pregnancy success for those with repeated miscarriages. This is based on the theory that sex hormone allergy exists, which is not widely accepted in medicine. The study is small with no comparison group.

26

Women with recurrent miscarriage and PMS

21 of 26

Women with improved PMS symptoms

16 of 26

Women with subsequent live births (61%)

## About the study

Original title Intradermal sex hormone desensitization for relief of premenstrual symptoms may improve the obstetric outcome of women with recurrent pregnancy loss Authors Itsekson AM, Soriano D, Zolti M et al. Journal Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Year 2013 Study design Non-randomised trial Participants 26 What was tested Small injections of estrogen and/or progesterone under the skin to desensitize Read the paper [doi.org/10.3109/09513590.2012.730582](https://doi.org/10.3109/09513590.2012.730582)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

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