--- title: Does the menstrual cycle or PMS change how the body processes pregnanolone? description: No. The study found no significant differences in how quickly pregnanolone is eliminated in women with PMS compared to healthy women, or between different pha url: https://niyora.com/research/papers/lack-of-influence-of-menstrual-cycle-and-premenstrual-syndrome-diagnosis-on-1999/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does the menstrual cycle or PMS change how the body processes pregnanolone? Case-control study, 1999 # Does the menstrual cycle or PMS change how the body processes pregnanolone? No. The study found no significant differences in how quickly pregnanolone is eliminated in women with PMS compared to healthy women, or between different phases of the menstrual cycle. Early or limited evidence 7 women with premenstrual syndrome and 7 healthy female controls ## What they did Seven women with PMS and seven healthy women received increasing doses of pregnanolone (a compound related to progesterone) during both the follicular phase (first half) and luteal phase (second half) of the menstrual cycle. Researchers measured how long it took the body to clear the drug. ## What they found The time for the body to clear half of a pregnanolone dose varied between 28.4 and 31.8 minutes across all women and cycle phases. Clearance rates varied between 59.6 and 64.0 ml per minute per kilogram. No significant differences were found between women with PMS and healthy women, or between cycle phases. ## What it means for you This small study suggests hormonal changes during the menstrual cycle and PMS do not significantly affect how the body processes pregnanolone. With only 7 women in each group, larger studies are needed to confirm these findings. 7 Women with PMS 7 Healthy control women 28.4-31.8 min Time to clear half the pregnanolone dose ## About the study Original title Lack of influence of menstrual cycle and premenstrual syndrome diagnosis on pregnanolone pharmacokinetics Authors Sundström I, Spigset O, Andersson A et al. Journal European journal of clinical pharmacology Year 1999 Study design Case-control study What was tested Pregnanolone doses given in different menstrual cycle phases Read the paper [doi.org/10.1007/s002280050606](https://doi.org/10.1007/s002280050606) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2026 How well do SSRIs treat PMS? Cohort study, 2026 Does having PMS before pregnancy increase the risk of postpartum depression? Systematic review, 2026 Why do some women experience mood changes linked to their menstrual cycle? Cohort study, 2026 Do premenstrual disorder and postpartum depression share the same genetic causes? Randomised trial, 2026 Does mindfulness training reduce PMS symptoms and fear about childbirth? Cohort study, 2025 Is there a link between premenstrual disorders and autoimmune disease? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗