---
title: Can GnRHa hormone therapy treat premenstrual syndrome long-term?
description: GnRHa treats PMS but causes about 8.2% bone loss in 6 months that may not fully reverse, creating a challenge for longer-term use.
url: https://niyora.com/research/papers/long-term-gonadotrophin-releasing-hormone-agonist-therapy-the-evolving-issue-of-1994/
---

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- Can GnRHa hormone therapy treat premenstrual syndrome long-term?

Review, 1994

# Can GnRHa hormone therapy treat premenstrual syndrome long-term?

GnRHa treats PMS but causes about 8.2% bone loss in 6 months that may not fully reverse, creating a challenge for longer-term use.

 Early or limited evidence

Individuals with premenstrual syndrome, endometriosis, fibroids, ovarian hyperandrogenism, and dysfunctional uterine bleeding

## What they did

Reviewed scientific literature on long-term GnRHa hormone therapy for conditions including PMS, endometriosis, fibroids, and others.

## What they found

GnRHa is used for PMS and related conditions. A 6-month course causes up to 8.2% decrease in lumbar bone density, which may not entirely reverse 6 months after stopping treatment.

## What it means for you

GnRHa can help PMS but the bone loss is a concern, especially for treatment lasting more than 6 months. Adding hormones back ('add-back' therapy) might reduce side effects, but researchers say more studies are needed.

8.2%

Decrease in lumbar bone density after 6 months of GnRHa

## About the study

Original title Long-term gonadotrophin-releasing hormone agonist therapy: the evolving issue of steroidal 'add-back' paradigms Authors Adashi EY Journal Human reproduction (Oxford, England) Year 1994 Study design Review What was tested Long-term GnRHa therapy with and without steroid add-back regimens Read the paper [doi.org/10.1093/oxfordjournals.humrep.a138715](https://doi.org/10.1093/oxfordjournals.humrep.a138715)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Endometriosis](https://niyora.com/research/topics/comorbidity-endometriosis/)

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