---
title: Can GnRHa hormone therapy treat premenstrual syndrome? | Niyora
description: GnRHa is used to treat PMS, but a 6-month course causes about 8.2% bone loss that may not fully recover, which is a concern for long-term use.
url: https://niyora.com/research/papers/long-term-gonadotropin-releasing-hormone-agonist-therapy-the-evolving-issue-of-1995/
---

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- Can GnRHa hormone therapy treat premenstrual syndrome?

Review, 1995

# Can GnRHa hormone therapy treat premenstrual syndrome?

GnRHa is used to treat PMS, but a 6-month course causes about 8.2% bone loss that may not fully recover, which is a concern for long-term use.

 Early or limited evidence

Individuals with premenstrual syndrome, endometriosis, fibroids, and related conditions

## What they did

Reviewed scientific literature on long-term GnRHa hormone therapy for various conditions including PMS, endometriosis, fibroids, and others.

## What they found

GnRHa is used to treat PMS and related conditions. A 6-month course of GnRHa is associated with up to 8.2% decrease in lumbar bone density, which may not be entirely reversible 6 months after stopping the drug.

## What it means for you

GnRHa can help PMS symptoms, but the bone loss is a significant drawback, especially if someone needs treatment longer than 6 months. The review suggests adding hormones back ('add-back' therapy) might reduce these side effects, but says more studies are needed.

8.2%

Decrease in lumbar bone density after 6 months of GnRHa

## About the study

Original title Long-term gonadotropin-releasing hormone agonist therapy: the evolving issue of steroidal "add-back" paradigms Authors Adashi EY Journal The Keio journal of medicine Year 1995 Study design Review What was tested Long-term GnRHa therapy with or without steroid add-back regimens Open access Yes Read the paper [doi.org/10.2302/kjm.44.124](https://doi.org/10.2302/kjm.44.124)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Endometriosis](https://niyora.com/research/topics/comorbidity-endometriosis/)

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