--- title: Does danazol help severe premenstrual syndrome? | Niyora description: Yes. Danazol was much more effective than placebo for overall symptoms and for specific symptoms including breast discomfort, irritability, mood swings, cryin url: https://niyora.com/research/papers/low-dose-danazol-in-the-treatment-of-the-premenstrual-syndrome-1991/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does danazol help severe premenstrual syndrome? Randomised trial, 1991 # Does danazol help severe premenstrual syndrome? Yes. Danazol was much more effective than placebo for overall symptoms and for specific symptoms including breast discomfort, irritability, mood swings, crying, low libido, and abdominal swelling. Moderate study design 37 women with severe premenstrual syndrome ## What they did Double-blind crossover study with 37 women with severe premenstrual syndrome. Nineteen women received danazol for 3 months followed by placebo; 18 women received placebo first then danazol. The dose was 100 mg twice daily. ## What they found Overall condition improved much more often with danazol than with placebo. Danazol provided clear improvement in breast discomfort, irritability, depression, anxiety, mood swings, crying, decreased libido, and abdominal swelling compared to placebo. ## What it means for you Danazol is effective and generally well tolerated for severe PMS. The study is small and uses a crossover design where women experienced both treatments in sequence, which may create some carryover effects. 37 women in study 100 mg danazol dose, twice daily 3 months treatment period ## About the study Original title Low dose danazol in the treatment of the premenstrual syndrome Authors Deeny M, Hawthorn R, McKay Hart D Journal Postgraduate medical journal Year 1991 Study design Randomised trial What was tested Danazol 100 mg twice daily for 3 months Open access Yes Read the paper [doi.org/10.1136/pgmj.67.787.450](https://doi.org/10.1136/pgmj.67.787.450) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2024 What are the best treatments for PMDD and PMS? Guideline, 2023 How are GnRH agonists used to treat PMDD that doesn't respond to standard medications? Review, 2022 What causes severe PMS and what treatments work? Systematic review, 2022 What are the best treatments for PMDD and PMS? Review, 2018 What are the most effective treatments for premenstrual syndrome and PMDD? Review, 2018 Which women are most likely to experience hot flashes during menopause? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗