---
title: Can the antidepressant nefazodone trigger mania in someone with undiagnosed bipolar disorder?
description: In this one reported case, a patient likely developed mania after starting nefazodone, suggesting the drug may be able to trigger mania, but a single case can
url: https://niyora.com/research/papers/micronized-progesterone-a-new-option-for-women-s-health-care-1999/
---

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- Can the antidepressant nefazodone trigger mania in someone with undiagnosed bipolar disorder?

Case report, 1999

# Can the antidepressant nefazodone trigger mania in someone with undiagnosed bipolar disorder?

In this one reported case, a patient likely developed mania after starting nefazodone, suggesting the drug may be able to trigger mania, but a single case cannot prove this happens generally.

 Early or limited evidence

One patient treated with the antidepressant nefazodone

## What they did

This was a report describing a single patient who developed symptoms of mania while being treated with the antidepressant nefazodone, and who had not previously been diagnosed with bipolar disorder. The report also discussed ideas about how this might have happened.

## What they found

The patient's mania was judged to be probably caused by the nefazodone treatment. The report notes that only one other case of mania linked to this drug had been published before this one.

## What it means for you

Because this is based on a single patient with no comparison group, it cannot prove that nefazodone generally causes mania. It may still be useful as a warning for doctors to watch for mania, especially in people who might have unrecognized bipolar disorder.

1

previously published similar case

## About the study

Original title Micronized progesterone: a new option for women's health care Authors Wetzel W Journal The Nurse practitioner Year 1999 Study design Case report What was tested The antidepressant nefazodone Read the paper [doi.org/10.1097/00006205-199905000-00005](https://doi.org/10.1097/00006205-199905000-00005)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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