---
title: Does myo-inositol help treat premenstrual dysphoric disorder symptoms?
description: Yes, myo-inositol significantly improved PMDD symptoms on three rating scales. Powder and capsule formulations worked similarly, though the study did not repo
url: https://niyora.com/research/papers/myo-inositol-in-the-treatment-of-premenstrual-dysphoric-disorder-2011/
---

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- Does myo-inositol help treat premenstrual dysphoric disorder symptoms?

Randomised trial, 2011

# Does myo-inositol help treat premenstrual dysphoric disorder symptoms?

Yes, myo-inositol significantly improved PMDD symptoms on three rating scales. Powder and capsule formulations worked similarly, though the study did not report how many women were treated.

 Early or limited evidence

Women with PMDD (sample size not reported in abstract)

## What they did

Two-phase randomized trial with a placebo washout period followed by treatment comparison. Women with PMDD received either myo-inositol as powder or soft gel capsules, or placebo. The number of participants was not reported in the abstract.

## What they found

Significant improvements were seen on the Daily Symptoms Records scale, Hamilton Depression Rating scale, and Clinical Global Impression-Severity scale. Both powder formulation (2 grams) and soft gel capsule formulation (0.6 grams) produced similar improvement.

## What it means for you

Myo-inositol appears effective for PMDD, with two formulations available. However, the study lacks key information: how many women were treated, how long treatment lasted, and whether results persisted after treatment ended. This limits confidence in the findings.

2g

powder formulation dose

0.6g

soft gel capsule dose

3

rating scales showed improvement

## About the study

Original title Myo-inositol in the treatment of premenstrual dysphoric disorder Authors Gianfranco C, Vittorio U, Silvia B et al. Journal Human psychopharmacology Year 2011 Study design Randomised trial What was tested Myo-inositol powder (2 grams) or soft gel capsules (0.6 grams) Read the paper [doi.org/10.1002/hup.1241](https://doi.org/10.1002/hup.1241)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

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