---
title: What conditions beyond depression can antidepressants treat? | Niyora
description: Newer antidepressants including SSRIs have FDA approval for several conditions including anxiety, obsessive-compulsive disorder, and panic disorder. Controlle
url: https://niyora.com/research/papers/new-indications-for-antidepressants-2000/
---

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- What conditions beyond depression can antidepressants treat?

Review, 2000

# What conditions beyond depression can antidepressants treat?

Newer antidepressants including SSRIs have FDA approval for several conditions including anxiety, obsessive-compulsive disorder, and panic disorder. Controlled studies also show they help premenstrual dysphoric disorder.

 Moderate study design

Various populations studied in controlled trials, including people with premenstrual dysphoric disorder

## What they did

This was a review of FDA approvals and controlled research on newer antidepressants for various conditions beyond major depression.

## What they found

Some newer antidepressants have FDA approval for generalized anxiety disorder, bulimia nervosa, obsessive-compulsive disorder, social phobia, panic disorder, and posttraumatic stress disorder. In controlled studies, these agents also showed effectiveness in premenstrual dysphoric disorder, borderline personality disorder, obesity, smoking cessation, and alcoholism.

## What it means for you

Antidepressants are useful for treating many conditions beyond depression, including PMDD. However, this is a review of evidence rather than a single study, and individual responses to medication vary.

## About the study

Original title New indications for antidepressants Authors Schatzberg AF Journal The Journal of clinical psychiatry Year 2000 Study design Review What was tested Various antidepressant medications (reviewed evidence) Read the paper [https://pubmed.ncbi.nlm.nih.gov/10926050/](https://pubmed.ncbi.nlm.nih.gov/10926050/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Stress](https://niyora.com/research/topics/symptom-stress/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Borderline personality disorder](https://niyora.com/research/topics/comorbidity-bpd/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Anxiety disorders and OCD](https://niyora.com/research/topics/comorbidity-anxiety-disorders/)[PTSD and trauma](https://niyora.com/research/topics/comorbidity-ptsd-trauma/)[Eating disorders](https://niyora.com/research/topics/comorbidity-eating-disorders/)[Alcohol, smoking and substance use](https://niyora.com/research/topics/comorbidity-substance-use/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Review, 1999

Is premenstrual dysphoric disorder a distinct clinical disorder?

Survey study, 2001

How common is premenstrual dysphoric disorder and how is it related to other psychiatric conditions?

Review, 1999

Do SSRI antidepressants work for PMDD?

Study, 2026

What are premenstrual syndrome and premenstrual dysphoric disorder?

Cohort study, 2022

How common are suicidal thoughts and self-harm in people with PMDD?

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