--- title: Can progesterone tablets help PMS? | Niyora description: Oral micronized progesterone appears suitable for treating PMS, with no reported side effects on heart health factors tested. However, this is a review, not a url: https://niyora.com/research/papers/oral-micronized-progesterone-bioavailability-pharmacokinetics-pharmacological-1987/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Can progesterone tablets help PMS? Review, 1987 # Can progesterone tablets help PMS? Oral micronized progesterone appears suitable for treating PMS, with no reported side effects on heart health factors tested. However, this is a review, not a clinical trial proving it works. Early or limited evidence Review of progesterone pharmacology and clinical applications ## What they did The authors reviewed the bioavailability, pharmacology, and therapeutic applications of oral micronized progesterone. ## What they found Oral micronized progesterone was developed to solve the problem of liver inactivation that prevented earlier forms of progesterone from working by mouth. At 200 mg daily, the preparation reproduces the anti-estrogenic effect of natural progesterone on the endometrium and its anti-mineralocorticoid effect. No side effects were reported regarding lipids profile, coagulation factors, or blood pressure. ## What it means for you Progesterone tablets might help PMS without increasing risks to the heart or blood clotting. However, this is a review describing potential use, not a clinical study showing it actually reduces PMS symptoms. The dose discussed is 200 mg daily. 200 mg Daily dose reproducing anti-estrogenic effect ## About the study Original title Oral micronized progesterone. Bioavailability pharmacokinetics, pharmacological and therapeutic implications--a review Authors Sitruk-Ware R, Bricaire C, De Lignieres B et al. Journal Contraception Year 1987 Study design Review Read the paper [doi.org/10.1016/0010-7824(87)90088-6](https://doi.org/10.1016/0010-7824(87)90088-6) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Mood swings and emotion regulation](https://niyora.com/research/topics/symptom-emotional-regulation/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2007 Is depression before a period linked to depression at menopause? Review, 2006 How do brain hormones affect PMDD and mood problems during the menstrual cycle? Cohort study, 2003 How does the menstrual cycle affect women's sleep? Case report, 2021 Can dydrogesterone help period pain, irregular cycles, PMS, and pregnancy loss, not just menopause? Non-randomised trial, 2014 Does hormone therapy help women with depression linked to periods and menopause? Study, 2009 Can the standard mental health diagnostic interview assess PMS and PMDD adequately? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗