---
title: Does paroxetine, an antidepressant, help PMDD symptoms? | Niyora
description: Clinical trials show evidence that paroxetine (an SSRI antidepressant) helps treat PMDD. This review summarizes what those trials found.
url: https://niyora.com/research/papers/paroxetine-treatment-of-mood-disorders-in-women-premenstrual-dysphoric-disorder-2003/
---

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- Does paroxetine, an antidepressant, help PMDD symptoms?

Review, 2003

# Does paroxetine, an antidepressant, help PMDD symptoms?

Clinical trials show evidence that paroxetine (an SSRI antidepressant) helps treat PMDD. This review summarizes what those trials found.

 Early or limited evidence

Women with PMDD (from trials reviewed)

## What they did

A review of clinical trial evidence for treating PMDD and hot flashes with paroxetine and its controlled-release formulation.

## What they found

Evidence for the efficacy of paroxetine in treating premenstrual dysphoric disorder has emerged from clinical trials.

## What it means for you

Paroxetine is a possible treatment for PMDD based on trial evidence. To know how well it works and for whom, you would need to read the individual trials reviewed here.

Paroxetine

medication tested

## About the study

Original title Paroxetine treatment of mood disorders in women: premenstrual dysphoric disorder and hot flashes Authors Yonkers KA Journal Psychopharmacology bulletin Year 2003 Study design Review What was tested Paroxetine, an SSRI antidepressant Read the paper [doi.org/10.64719/pb.7067](https://doi.org/10.64719/pb.7067)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Review, 2011

What are PMS and PMDD, and how common are they?

Review, 2012

Is depression linked to hormonal changes during the menstrual cycle, pregnancy, and menopause?

Review, 2004

How should PMDD be treated with antidepressants?

Review, 2002

What are the reproductive-related mood disorders and how are they connected?

Survey study, 2002

What treatments work for depression linked to the menstrual cycle and PMDD?

Guideline, 2001

What is the best treatment for PMDD and depression in women?

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