--- title: Do serotonin levels affect mood in girls with PMS? | Niyora description: Yes. Girls with PMS who had lower serotonin levels experienced more mood changes. Serotonin affected mood only in girls with PMS, not in those without it. url: https://niyora.com/research/papers/pengaruh-serotonin-terhadap-perubahan-mood-pada-remaja-wanita-premenstrual-2023/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do serotonin levels affect mood in girls with PMS? Survey study, 2023 # Do serotonin levels affect mood in girls with PMS? Yes. Girls with PMS who had lower serotonin levels experienced more mood changes. Serotonin affected mood only in girls with PMS, not in those without it. Early or limited evidence 48 adolescent girls in Makassar, Indonesia (24 with PMS, 24 without) ## What they did Cross-sectional study of 48 adolescent girls in Makassar, Indonesia from April to July 2023. The researchers divided girls into two groups of 24 each (with PMS and without PMS) and measured serotonin levels and mood changes in both groups. ## What they found Serotonin levels were significantly different between the PMS and non-PMS groups (p=0.012). In the PMS group, lower serotonin was linked to greater mood changes (p=0.001). In the non-PMS group, serotonin levels did not affect mood changes (p=0.875). ## What it means for you Low serotonin may contribute to mood swings in PMS. The study measured serotonin only once and was small, so it is unclear whether low serotonin causes PMS mood symptoms or is a result of them. Treatment approaches for PMS beyond serotonin regulation alone may be needed. 48 adolescent girls total p=0.012 serotonin difference between groups p=0.001 serotonin effect on mood ## About the study Original title PENGARUH SEROTONIN TERHADAP PERUBAHAN MOOD PADA REMAJA WANITA PREMENSTRUAL SYNDROME Authors Ruqaiyah Ruqaiyah, Hadriani Irwan, Alamsyah Alamsyah et al. Journal Media Penelitian dan Pengembangan Kesehatan Year 2023 Study design Survey study Participants 48 Open access Yes Read the paper [doi.org/10.34011/jmp2k.v33i3.1750](https://doi.org/10.34011/jmp2k.v33i3.1750) Original abstract A woman's regular monthly menstruation is positive indicator of health. However, majority of women have negative effects from symptoms arising during the second half of the menstrual cycle. This study aims to determine the effect of serotonin on mood changes in adolescent girls suffering from PMS and who don't. This research was conducted in April-July 2023 at Darul Arqam in Makassar. The research used a cross-sectional design with a sample size of 48 young women consisting of two groups, 24 groups with PMS and 24 without PMS, selected using purposive sampling. Mann-Whitney and Kruskall-Wallis analyses were used to examine the effect of serotonin on changes in mood and menstrual patterns in adolescent girls with and without PMS. The finding showed that there were differences in serotonin levels between groups of women who experienced PMS and those who did not experience PMS, with a value of p=0.012 p<α=0.05. The findings showed an influence of serotonin levels in the group of women who experienced PMS on mood changes (p = 0.001). In the group of women who did not experience PMS, serotonin levels did not influence mood changes (p = 0.875). Serotonin influences mood changes in women who experience PMS. However, serotonin does not have positive or negative effects on women who have not experienced PMS. There are differences in serotonin levels between women who experience PMS and those who don't. This study recommends to explore alternative treatment options for managing PMS symptoms that do not rely solely on serotonin regulation. Reproduced under CC-BY-SA. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2026 Does aerobic or resistance exercise reduce anxiety in women with PMS? Cohort study, 2025 How common is PMS in Chinese teenage girls, and what factors are linked to it? Systematic review, 2025 Does alcohol use affect menstrual health in teenage girls? Systematic review, 2025 Does teaching adolescent girls about their menstrual cycle and health help reduce period pain and PMS? Randomised trial, 2024 Does curcumin-piperine combination improve antioxidant activity in women with PMS and period pain? Systematic review, 2024 How common is premenstrual syndrome in Africa, and what factors increase the risk? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗